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Prolactin and Psychopathology in Schizophrenia: A Literature Review and Reappraisal

机译:精神分裂症的催乳素和精神病理学:文献综述和重新评估

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摘要

Secretion of the anterior pituitary hormone prolactin can be significantly increased by antipsychotic drugs, leading to a range of adverse effects in patients with schizophrenia. However, there is evidence from a variety of studies that prolactin may also be related to symptom profile and treatment response in these patients, and recent work has identified variations in prolactin secretion even in drug-free patients. In this paper, a selective review of all relevant studies pertaining to prolactin and schizophrenia, including challenge and provocation studies, is presented. The implications of this work are discussed critically. A tentative model, which synthesizes these findings and argues for a significant role for prolactin in the development of schizophrenia, is outlined.
机译:抗精神病药物可以显着增加前垂体激素催乳素的分泌,导致精神分裂症患者的一系列不利影响。然而,有来自各种研究的证据,催乳素也可能与这些患者的症状曲线和治疗反应有关,即使在无毒患者中,最近的工作也鉴定了催乳素分泌的变化。在本文中,提出了对尿猴和精神分裂症有关的所有相关研究的选择性审查,包括挑战和挑衅性研究。这项工作的含义批判性地讨论。初步模型,合成这些发现并争论在精神分裂症发育中催乳素的重要作用,是概述的。

著录项

  • 作者

    Ravi Philip Rajkumar;

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  • 年度 2014
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  • 原文格式 PDF
  • 正文语种 eng
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