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首页> 外文期刊>Otolaryngology--head and neck surgery: official journal of American Academy of Otolaryngology-Head and Neck Surgery >Adenotonsillar enlargement in pediatric organ transplant recipients: a cross-sectional analysis.
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Adenotonsillar enlargement in pediatric organ transplant recipients: a cross-sectional analysis.

机译：小儿器官移植受者腺扁桃体增大：横断面分析。

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OBJECTIVE: Our goal was to statistically correlate adenotonsillar hypertrophy (ATH) in the pediatric posttransplant population with potential risk factors and to monitor the progression of ATH over time. STUDY DESIGN AND SETTING: Participants were evaluated for ATH through a standardized 65-point questionnaire and an 8-point physical examination. They were also evaluated for current age, age at time of transplantation, type of organ transplant, gender, tacrolimus use, history of transplant rejection, Epstein-Barr virus (EBV) serology, and cytomegalovirus (CMV) serology. We evaluated 243 pediatric solid organ transplant recipients, with 116 patients undergoing repeat evaluation. RESULTS: A statistically significant negative correlation was noted between age at time of transplantation and both questionnaire scores (P = 0.0075) and examination scores (P = 0.013). A significant negative correlation was also seen between age at time of evaluation and questionnaire score (P = 0.028) but not examination score (P = 0.49). Recipient EBV seronegativity significantly increased questionnaire score (P = 0.05). Liver transplant recipients also had a significantly higher questionnaire score than did kidney transplant recipients (P = 0.0048). Gender, CMV recipient status, and tacrolimus (immunosuppressant) use did not significantly impact questionnaire or examination scores. Repeat evaluation of 116 patients after a 2- to 9-month interval did not demonstrate any significant increases in questionnaire scores. A statistically significant drop in examination scores was noted (P = 0.003). Conclusions and Significance: These findings support previous reports in the literature that correlate EBV seronegativity, younger age at transplant, and liver versus kidney transplantation with increased incidence of PTLD.
机译：目的：我们的目标是统计儿科移植后人群的腺扁桃体肥大（ATH）与潜在危险因素，并监测ATH随时间的进展。研究设计和设置：通过标准化的65点问卷和8点身体检查对参与者的ATH进行评估。还对他们的年龄，移植年龄，器官移植类型，性别，他克莫司的使用，移植排斥史，爱泼斯坦-巴尔病毒（EBV）血清学和巨细胞病毒（CMV）血清学进行了评估。我们评估了243名儿科实体器官移植受者，其中116例患者接受了重复评估。结果：移植时的年龄与问卷评分（P = 0.0075）和检查评分（P = 0.013）之间存在统计学上的显着负相关。在评估时的年龄和问卷得分之间也发现了显着的负相关（P = 0.028），但在检查得分上却没有（P = 0.49）。接受者EBV血清阴性反应显着增加了问卷评分（P = 0.05）。肝移植接受者的问卷调查得分也明显高于肾移植接受者（P = 0.0048）。性别，CMV接受者状态和他克莫司（免疫抑制剂）的使用对问卷或检查分数没有显着影响。在2到9个月的间隔后对116例患者进行重复评估并未显示问卷得分有任何显着增加。注意到考试成绩在统计学上显着下降（P = 0.003）。结论和意义：这些发现支持以前的文献报道，这些文献将EBV血清阴性，移植时的年龄降低以及肝移植和肾移植与PTLD发生率增加相关。

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