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首页> 外文期刊>Otolaryngology--head and neck surgery: official journal of American Academy of Otolaryngology-Head and Neck Surgery >Local production of antigen-specific IgE in different anatomic subsites of allergic fungal rhinosinusitis patients.
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Local production of antigen-specific IgE in different anatomic subsites of allergic fungal rhinosinusitis patients.

机译：在过敏性真菌鼻-鼻窦炎患者的不同解剖亚位中局部产生抗原特异性IgE。

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OBJECTIVE: Local production of antigen-specific IgE in allergic fungal rhinosinusitis (AFRS) is likely integral to the expression of allergy. This study examines if there are anatomic variations in local IgE expression or if variations among fungal and nonfungal IgE exist. STUDY DESIGN: Cross-sectional study. SETTING: Tertiary medical center. SUBJECTS AND METHODS: Specimens from 11 AFRS, 8 chronic rhinosinusitis without nasal polyps (CRSsNP), and 9 control patients underwent immunohistochemical localization for IgE and evaluation for antigen-specific IgE by ImmunoCAP testing. RESULTS: Inferior turbinate (IT) epithelium had greater IgE staining in AFRS than control (P=0.013) and CRSsNP (P=0.002). A significant difference was also found at the IT subepithelial level for AFRS compared with controls (P=0.001) and CRSsNP (P<0.001). Within AFRS, IgE staining was increased in the subepithelium compared to epithelium (P=0.003). ImmunoCAP analysis on IT tissue from AFRS and controls demonstrated increased antigen-specific IgE for 5 of 14 antigens (P<0.05) and total IgE (P<0.001). There were no significant anatomic differences between IT and sinus IgE staining. CONCLUSION: More fungal and nonfungal IgE is expressed in IT and sinus tissues of AFRS patients, as compared with control and CRSsNP patients.
机译：目的：在过敏性真菌性鼻鼻窦炎（AFRS）中局部产生抗原特异性IgE可能是变态反应表达不可或缺的部分。这项研究检查了局部IgE表达是否存在解剖学变异，或者真菌和非真菌IgE之间是否存在变异。研究设计：横断面研究。地点：第三级医疗中心。研究对象和方法：对11例AFRS，8例无鼻息肉的慢性鼻鼻窦炎（CRSsNP）和9例对照患者的标本进行了免疫组化IgE定位，并通过ImmunoCAP测试评估了抗原特异性IgE。结果：AFRS中下鼻甲（IT）上皮的IgE染色高于对照组（P = 0.013）和CRSsNP（P = 0.002）。与对照组（P = 0.001）和CRSsNP（P <0.001）相比，AFRS的IT上皮下水平也存在显着差异。在AFRS中，与上皮相比，上皮下IgE染色增加（P = 0.003）。对来自AFRS和对照的IT组织进行的ImmunoCAP分析表明，针对14种抗原中的5种，抗原特异性IgE升高（P <0.05），总IgE升高（P <0.001）。 IT和窦IgE染色之间没有明显的解剖学差异。结论：与对照组和CRSsNP患者相比，AFRS患者的IT和窦组织中表达的真菌和非真菌IgE更多。

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