Development of the Large-Scale Preparation of 2-(Methanesulfonyl)benzenesulfonyl Chloride

Harold Meckler; R. Jason Herr

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Development of the Large-Scale Preparation of 2-(Methanesulfonyl)benzenesulfonyl Chloride

机译：大规模制备2-（甲磺酰基）苯磺酰氯的研制

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A practical and scalable process is described for the preparation of 2-(methansulfonyl)benzenesulfonyl chloride, a key building block used in the synthesis of several drug candidates. The material is prepared by an efficient four-step sequence from inexpensive 1,2-dichlorobenzene and methanethiol, and the process has been demonstrated on a multikilogram scale in 32% overall yield with a chemical purity of >98%.

机译：描述了一种实用且可扩展的方法，用于制备2-（甲磺酰基）苯磺酰氯，这是用于合成几种候选药物的关键组成部分。该材料是通过高效的四步法从廉价的1,2-二氯苯和甲硫醇制备的，该方法已在多千克规模上以32％的总收率进行了证明，化学纯度> 98％。

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《Organic process research & development》 |2012年第4期|共6页
作者
Harold Meckler; R. Jason Herr;
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正文语种 eng
中图分类化学工业;
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1. Development of the Large-Scale Preparation of 2-(Methanesulfonyl)benzenesulfonyl Chloride [J] . Harold Meckler, R. Jason Herr Organic process research & development . 2012,第4期

机译：大规模制备2-（甲磺酰基）苯磺酰氯的研制
2. The Reactions of 2-(Bromoseleno)benzenesulfonyl Chloride with Primary Amines toward 2,2' -Diselenobis(benzenesulfonamides) and 1,3,2-Benzothiaselenazole 1,1-Dioxides:New Oxygen-Transfer Agents,Antimicrobials and Virucides [J] . P.Potaczek, M.Giurg, K.Kloc, Polish Journal of Chemistry . 2004,第5期

机译：2-（溴代硒代）苯磺酰氯与伯胺向2,2'-二硒双（苯磺酰胺）和1,3,2-苯并噻吩并恶唑1,1-二氧化物的反应：新型氧转移剂，抗菌剂和杀病毒剂
3. 4-(5',6'-DIMETHOXYBENZOTHIAZOLYL)BENZOYL FLUORIDE AND 2-(5',6'-DIMETHOXYBENZOTHIAZOLYL)BENZENESULFONYL CHLORIDE AS SENSITIVE FLUORESCENCE DERIVATIZATION REAGENTS FOR AMINES IN HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY [J] . Hara S., Yoshikuni K., Tatsuguchi Y., The Analyst: The Analytical Journal of the Royal Society of Chemistry: A Monthly International Publication Dealing with All Branches of Analytical Chemistry . 1997,第5期

机译：4-（5'，6'-二甲氧基苯并噻唑基）苯甲酰氟和2-（5'，6'-二甲氧基苯并噻唑基）苯甲磺酰氯作为灵敏的荧光衍生试剂，用于高效液相色谱中的酰胺
4. Development of a Robotic Platform for Automated GCMS and LCMS Sample Preparation and Large-scale Plant Metabolomics [C] . David V. Huhman, Nicky Eastham, Graham Ellison, ASMS Conference on Mass Spectrometry and Allied Topics . 2015

机译：开发自动化GCMS的机器人平台和LCMS样品制备和大规模植物代谢组学
5. Gold nanoparticles: Tailored preparation and assembly in 2- and 3-dimensions. [D] . Corbierre, Muriel K. 2004

机译：金纳米颗粒：二维和量身定制的制备和组装。
6. Post-Synthetic Derivatization of Graphitic Carbon Nitride with Methanesulfonyl Chloride: Synthesis Characterization and Photocatalysis [O] . Petr Praus, Aneta Smýkalová, Kryštof Foniok, 2020

机译：甲磺酰氯对石墨化氮化碳的后合成衍生反应：合成表征和光催化
7. Preparation of methanesulfonyl chloride-d3 from dimethyl sulfoxide-d6. [O] . KAZUHIKO HANAI, TAKACHIYO OKUDA 1977

机译：二甲基磺氧化物-D6制备甲磺酰氯-D3。

Development of the Large-Scale Preparation of 2-(Methanesulfonyl)benzenesulfonyl Chloride

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