Asymmetric Synthesis of a TRPV1 Antagonist via tert-Butanesulfinamide-Directed Reductive Amination with a Chromanone

Mary E. Bellizzi; Ashok V. Bhatia; Steven C. Cullen

首页> 外文期刊>Organic process research & development >Asymmetric Synthesis of a TRPV1 Antagonist via tert-Butanesulfinamide-Directed Reductive Amination with a Chromanone

【24h】

Asymmetric Synthesis of a TRPV1 Antagonist via tert-Butanesulfinamide-Directed Reductive Amination with a Chromanone

机译：通过叔丁烷亚磺酰胺定向的氨基甲酸酯还原还原胺的不对称合成TRPV1拮抗剂。

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

An expedient asymmetric synthesis of TRPV1 antagonist 1 has been developed and demonstrated on multikilogram scale. The enabling route to 1 is detailed herein and characterized by the following key transformations: an aldol-cyclodehydration sequence to install the chromanone, and an auxiliary-mediated diastereoselective reductive amination.

机译：已经开发了权宜的TRPV1拮抗剂1的不对称合成，并已在多千克规模上得到了证明。到1的实现途径在此进行了详细说明，其特征在于以下关键转换：安装苯并二氢吡喃酮的羟醛-环脱水序列和辅助介导的非对映选择性还原胺化反应。

著录项

来源
《Organic process research & development》 |2014年第2期|共7页
作者
Mary E. Bellizzi; Ashok V. Bhatia; Steven C. Cullen;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类化学工业;
关键词

相似文献

外文文献
中文文献
专利

1. Asymmetric Synthesis of a TRPV1 Antagonist via tert-Butanesulfinamide-Directed Reductive Amination with a Chromanone [J] . Mary E. Bellizzi, Ashok V. Bhatia, Steven C. Cullen Organic process research & development . 2014,第2期

机译：通过叔丁烷亚磺酰胺定向的氨基甲酸酯还原还原胺的不对称合成TRPV1拮抗剂。
2. Development of a large scale asymmetric synthesis of vanilloid receptor (TRPV1) antagonist ABT-102 [J] . Lukin K, Hsu MC, Chambournier G, Organic process research & development . 2007,第3期

机译：大规模不对称合成香草酸受体（TRPV1）拮抗剂ABT-102的开发
3. Direct Synthesis of Chiral NH Lactams via Ru-Catalyzed Asymmetric Reductive Amination/Cyclization Cascade of Keto Acids/Esters [J] . Shi Yongjie, Tan Xuefeng, Gao Shuang, Organic letters . 2020,第7期

机译：通过Ru催化的不对称还原胺化/环化级联的酮酸/酯直接合成手性NH内酰胺蛋白
4. Development of a commercial scale direct asymmetric reductive amination (DARA) reaction [C] . Scott A. Frank Process Development Symposium . 2013

机译：开发商业规模直接不对称还原胺化（DARA）反应
5. Part I. Synthesis of Garner's Aldehyde and Efforts Toward the Synthesis of Tapentadol via an Asymmetric Hydroformylation/Reductive Amination Sequence Part II. Development of a Rhodium-Mediated Domino Annulation and Efforts Toward the Total Synthesis of Linderagalactone C. [D] . Clemens, Alexander John Lee. 2012

机译：第一部分。加纳醛的合成及其通过不对称加氢甲酰化/还原胺化序列合成塔潘多尔的努力第二部分。铑介导的多米诺骨环的发展及全合成Linderagalactone C的努力。
6. Intramolecular asymmetric reductive amination: synthesis of enantioenriched dibenzceazepines [O] . Tao Yang, Xiaochong Guo, Qin Yin, 2019

机译：分子内不对称还原胺化：对映体富集的苯并ce庚因的合成
7. Asymmetric Synthesis of N ‐Substituted α‐Amino Esters from α‐Ketoesters via Imine Reductase‐Catalyzed Reductive Amination [O] . Peiyuan Yao, James R. Marshall, Zefei Xu, 2021

机译：通过亚胺还原酶催化的还原胺化来自α-酮酯的N-仲丁α-氨基酯的不对称合成

Asymmetric Synthesis of a TRPV1 Antagonist via tert-Butanesulfinamide-Directed Reductive Amination with a Chromanone

摘要

著录项

相似文献

相关主题

期刊订阅