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首页> 外文期刊>Scandinavian journal of clinical and laboratory investigation. >Differences in acute metabolism of fructose between hemodialysis patients and healthy subjects
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Differences in acute metabolism of fructose between hemodialysis patients and healthy subjects

机译：血液透析患者和健康受试者之间果糖急性代谢的差异

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The consumption of fructose has increased dramatically during the last few decades and parallels the epidemics of obesity, metabolic syndrome, diabetes and chronic kidney disease (CKD). Fructose occurs naturally e.g. in fruit and in honey (rich in this monosaccharide) and as sucrose (table sugar). The effects of fructose have been attributed to the transient increases in serum uric acid levels during its metabolism. Recent research, also in CKD patients, has linked fructose to dysmetabolism of lipids, glucose and oxidative radicals. However, a general consensus of the potentially harmful effects of fructose is lacking. We improved a sensitive inulin assay for fructose measurement in serum and plasma and tested its accuracy in an acute experiment following consumption of pure fructose in controls. In addition, fructose and uric acid were analyzed postprandially during 240 min in six maintenance hemodialysis (HD) patients and nine healthy subjects consuming 190 ml cream/75 g sucrose in a fasting state. Whereas the fructose levels reached a maximum level after 60 min in controls they had not even started to decrease at 240 min in HD-patients. Likewise, while uric acid levels remained stable in controls they increased by 10% in HD patients at 240 min following the meal. In conclusion, a glucose and fat rich meal is associated with delayed absorption and/or metabolism of fructose in HD patients as well as increased serum uric acid levels.
机译：在过去的几十年中，果糖的消耗量急剧增加，与肥胖，代谢综合症，糖尿病和慢性肾脏病（CKD）的流行相提并论。果糖自然存在，例如。在水果和蜂蜜中（富含这种单糖）和蔗糖（食用糖）。果糖的作用归因于其代谢过程中血清尿酸水平的短暂升高。最近对CKD患者的研究也将果糖与脂质，葡萄糖和氧化自由基的代谢异常有关。但是，关于果糖的潜在有害作用缺乏普遍共识。我们改进了用于血清和血浆中果糖测定的灵敏菊粉测定法，并在对照组中食用纯果糖后的急性实验中测试了其准确性。此外，在六名维持性血液透析（HD）患者和九名健康的受试者中，在餐后240分钟的餐后对果糖和尿酸进行了分析，这些受试者在空腹状态下摄入190 ml奶油/ 75 g蔗糖。而对照中果糖水平在60分钟后达到最高水平，而HD患者在240分钟时果糖水平甚至没有开始下降。同样，尽管对照组中的尿酸水平保持稳定，但在餐后240分钟时，HD患者的尿酸水平却增加了10％。总之，富含葡萄糖和脂肪的膳食与HD患者果糖的吸收和/或代谢延迟以及血清尿酸水平升高有关。

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