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首页> 外文期刊>Scandinavian journal of immunology. >Effect of high fat diet on NKT cell function and NKT cell-mediated regulation of Th1 responses.
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Effect of high fat diet on NKT cell function and NKT cell-mediated regulation of Th1 responses.

机译：高脂饮食对NKT细胞功能和NKT细胞介导的Th1反应调节的影响。

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Diet is one of the important factors that modulate immune responses. In the present study, we have examined the capacity of dietary lipids to modify immune responses in mice and we have investigated the contribution of glycolipid-reactive natural killer T (NKT) cells in this process. Mice fed, high fat diet (HFD; 21.2% fat, 0.20% cholesterol) for 3 weeks, as compared with mice fed standard fat diet (SFD; 4.3% fat, 0.03% cholesterol), showed significantly reduced interferon-gamma production in sera at 6 or 12 h after intraperitoneal injection of an NKT cell ligand, alpha-galactosylceramide. In contrast, production of interleukin-13 was significantly higher at 2 and 6 h in HFD fed mice compared with mice on SFD. No difference was detected in the serum interleukin-4 levels between these two groups of animals. The proportion of NKT cells in spleen and liver was reduced in mice fed HFD compared with those on SFD. In addition, activation of NKT cells assessed by up-regulation of CD69 was suppressed specifically in liver from mice fed HFD. Recall responses of conventional T cells and delayed-type hypersensitivity (Th1 type) against ovalbumin were significantly suppressed in mice fed HFD in comparison with those fed SFD. This suppression was not observed in CD1d-/- mice, suggesting that NKT cells in mice fed HFD played a role in suppressing Th1 responses. Taken together, our findings suggest a critical link between NKT cells, dietary lipid and adaptive immune responses.
机译：饮食是调节免疫反应的重要因素之一。在本研究中，我们研究了饮食脂质改变小鼠免疫反应的能力，并研究了糖脂反应性自然杀伤T细胞（NKT）在此过程中的作用。饲喂高脂饮食（HFD; 21.2％脂肪，0.20％胆固醇）3周的小鼠，与喂食标准脂肪饮食（SFD; 4.3％脂肪，0.03％胆固醇）的小鼠相比，血清中干扰素-γ的产生显着降低在腹膜内注射NKT细胞配体α-半乳糖基神经酰胺后6或12小时。相比之下，与喂食SFD的小鼠相比，喂食HFD的小鼠在2和6 h时白细胞介素13的产量明显更高。两组动物之间的血清白介素4水平没有差异。与SFD相比，HFD喂养的小鼠脾脏和肝脏中NKT细胞的比例降低。另外，用HFD喂养的小鼠的肝脏中，通过CD69上调评估的NKT细胞的激活被特异性抑制。与饲喂SFD的小鼠相比，饲喂HFD的小鼠显着抑制了常规T细胞的召回反应和对卵清蛋白的迟发型超敏反应（Th1型）。在CD1d //-小鼠中未观察到这种抑制作用，表明喂食HFD的小鼠中的NKT细胞在抑制Th1反应中发挥了作用。两者合计，我们的发现表明NKT细胞，饮食脂质和适应性免疫反应之间的关键联系。

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