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首页> 外文期刊>Scandinavian journal of infectious diseases. >Staphylococcus aureus bacteremia: a 14-year nationwide study in hematological patients with malignant disease or agranulocytosis.
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Staphylococcus aureus bacteremia: a 14-year nationwide study in hematological patients with malignant disease or agranulocytosis.

机译:金黄色葡萄球菌菌血症:一项针对恶性疾病或粒细胞缺乏症的血液病患者的为期14年的全国性研究。

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摘要

This retrospective nationwide study of 756 cases of S. aureus bacteremia in hematological patients, between 1977-1990, confirms that S. aureus bacteremia is disproportionately prevalent among, and a major cause of morbidity and mortality in, hematological patients. The case mortality rate attributable to S. aureus bacteremia (44%) was significantly higher than the rate (29%) found in patients without hematological disease. A decreasing mortality was, however, observed from the first to the last part of the study period (53 and 37% respectively). A logistic regression analysis showed that mortality was further dependent on age, the type of hematological disease and origin of infection/primary focus of infection. Analysis of clinical features confirmed that in comparison with other patients, S. aureus bacteremia in hematological patients more often was hospital-acquired, acquired without known portal of infection/primary focus of infection and much less frequently resulted in osteomyelitis or endocarditis. From phage typing and antibiotic susceptibility patterns no specific types of S. aureus were associated with hematological patients.
机译:这项对1977-1990年间血液病患者中756例金黄色葡萄球菌菌血症的全国性回顾性研究证实,金黄色葡萄球菌菌血症在血液病患者中不成比例地流行,并且是发病率和死亡率的主要原因。金黄色葡萄球菌菌血症引起的病例死亡率(44%)显着高于无血液系统疾病患者的死亡率(29%)。但是,从研究期的第一部分到最后部分观察到死亡率降低(分别为53%和37%)。逻辑回归分析表明,死亡率进一步取决于年龄,血液疾病类型和感染源/主要感染源。临床特征分析证实,与其他患者相比,血液学患者中的金黄色葡萄球菌菌血症更多地是医院获得的,是在没有已知的感染门/主要感染源的情况下获得的,而导致骨髓炎或心内膜炎的频率则更低。从噬菌体分型和抗生素敏感性模式来看,血液学患者没有特定类型的金黄色葡萄球菌。

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