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首页> 外文期刊>Scandinavian journal of infectious diseases. >Prevention of hepatitis B by immunization of the newborn infant--a long-term follow-up study in Stockholm, Sweden.
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Prevention of hepatitis B by immunization of the newborn infant--a long-term follow-up study in Stockholm, Sweden.

机译：通过新生儿免疫预防乙型肝炎-瑞典斯德哥尔摩的一项长期随访研究。

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In order to assess the present hepatitis B immunization program in Stockholm, Sweden, 212 children of HBsAg carrier mothers were followed up 2-9 years after birth. In babies of HBeAg-positive mothers a combined passive and active immunization schedule with hepatitis B immunoglobulin (HBIG) and hepatitis B vaccine was used. Among 25 children to such mothers, 1 HBsAg carrier and 5 children with asymptomatic seroconversion were found. To newborns of HBeAg-negative/anti-HBe-negative mothers, only vaccine was given. Among 15 such children, no HBsAg carrier (but 1 child with an asymptomatic seroconversion) was found. In babies of HBeAg-negative/anti-HBe-positive mothers, immunization was withheld between 1983 and 1987. Among 90 such children, 1 HBsAg carrier and 8 asymptomatic seroconversions were detected. After 1987, newborns in this group were vaccinated whereafter 3 asymptomatic seroconversions were found among 82 children. We conclude that in low prevalence areas a screening program for HBsAg should be offered to pregnant women originating from hepatitis B endemic regions, since immunoprophylaxis gave long-term protection to most children at risk. Children born to HBeAg-positive mothers should receive vaccine in combination with HBIg, whereas for children of mothers lacking HBeAg, vaccination only seems sufficient, at least if a rapid vaccination schedule is used.
机译：为了评估瑞典斯德哥尔摩目前的乙型肝炎免疫接种计划，对出生后2-9岁的212名HBsAg携带者母亲进行了随访。在HBeAg阳性母亲的婴儿中，采用了结合了乙型肝炎免疫球蛋白（HBIG）和乙型肝炎疫苗的被动和主动免疫方案。在这些母亲的25名儿童中，发现1名HBsAg携带者和5名无症状血清转换的儿童。对于HBeAg阴性/抗HBe阴性母亲的新生儿，仅接种疫苗。在15名此类儿童中，未发现HBsAg携带者（但1名儿童无症状血清转化）。在1983年至1987年之间，HBeAg阴性/抗HBe阳性的婴儿被免疫。在90例此类儿童中，检测到1例HBsAg携带者和8例无症状的血清转化。 1987年后，对该组新生儿进行了疫苗接种，此后在82名儿童中发现了3例无症状的血清转化。我们的结论是，在低流行地区，应为来自乙型肝炎流行地区的孕妇提供HBsAg筛查计划，因为免疫预防为大多数处于危险中的儿童提供了长期保护。 HBeAg阳性母亲所生的孩子应与HBIg一起接种疫苗，而对于缺乏HBeAg的母亲的孩子来说，疫苗接种似乎才足够，至少要采用快速疫苗接种计划。

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