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首页> 外文期刊>Seminars in cell and developmental biology >Intracellular and intercellular signaling networks in cancer initiation, development and precision anti-cancer therapy RAS acts as contextual signaling hub
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Intracellular and intercellular signaling networks in cancer initiation, development and precision anti-cancer therapy RAS acts as contextual signaling hub

机译：癌症发生，发展和精确抗癌治疗中的细胞内和细胞间信号网络RAS作为背景信号枢纽

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Cancer initiation and development are increasingly perceived as systems-level phenomena, where intraand inter-cellular signaling networks of the ecosystem of cancer and stromal cells offer efficient methodologies for outcome prediction and intervention design. Within this framework, RAS emerges as a 'contextual signaling hub', i.e. the final result of RAS activation or inhibition is determined by the signaling network context. Current therapies often 'train' cancer cells shifting them to a novel attractor, which has increased metastatic potential and drug resistance. The few therapy-surviving cancer cells are surrounded by massive cell death triggering a primordial adaptive and reparative general wound healing response. Overall, dynamic analysis of patient- and disease-stage specific intracellular and intercellular signaling networks may open new areas of anticancer therapy using multitarget drugs, drugs combinations, edgetic drugs, as well as help design 'gentler', differentiation and maintenance therapies. (C) 2016 Elsevier Ltd. All rights reserved.
机译：癌症的发生和发展越来越被认为是系统级的现象，癌症和基质细胞生态系统的细胞内和细胞间信号网络为结果预测和干预设计提供了有效的方法。在此框架内，RAS成为“上下文信令中心”，即RAS激活或抑制的最终结果由信令网络上下文确定。当前的治疗方法经常“训练”癌细胞，使其转移到新的吸引子上，从而增加了转移潜力和耐药性。少数能存活治疗的癌细胞被大量细胞死亡所包围，引发原始的适应性和修复性一般伤口愈合反应。总体而言，对患者和疾病阶段特定的细胞内和细胞间信号网络的动态分析可能会开辟使用多靶点药物，药物组合，边缘药物的抗癌治疗新领域，并有助于设计“温和的”，分化和维持疗法。 （C）2016 Elsevier Ltd.保留所有权利。

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