• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Seizure: the journal of the British Epilepsy Association >Vagus nerve stimulation for medically refractory absence epilepsy
【24h】

Vagus nerve stimulation for medically refractory absence epilepsy

机译：迷走神经刺激治疗难治性癫痫

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Purpose: A proportion of patients with childhood and juvenile absence epilepsies (CAE, JAE) are likely to be classified as medically refractory. In view of evidence gap for the treatment of such patients, this series is reported to generate estimate for efficacy of vagus nerve stimulation (VNS) in this patient population. Methods: Patients were identified by a chart review of all VNS recipients between January 1, 2006 and December 31, 2011. The diagnosis of CAE and JAE was based on conventional criteria. Details of demography, epilepsy phenomenology, management and outcomes were extracted. The outcome measures included reduction in daily seizure frequency measured as a percentage of pre-VNS seizure frequency and classified on International League Against Epilepsy (ILAE) outcome scale. Results: Nine patients (7 CAE, 2 JAE) with a mean age of seizure onset of 5.4 years (±3.9) were identified. Mean duration of epilepsy prior to VNS implant was found to be 3.9 years (±1.4). These patients had failed a median of 5 anti-epileptic drugs before being referred for consideration of surgical treatment. After a mean follow-up of 33.9 months (±25.5, minimum 4 months), 1 patient attained complete seizure freedom (ILAE class 1), 6 had ILAE class 4 and 2 had ILAE class 5 outcomes, respectively. Mean reduction in daily seizure frequency was found to be 53.5 ± 60.3% (1-sided p-value for paired t-test = 0.04), with a 50% responder rate of 55.6%. Conclusion: VNS may be considered as a therapeutic option in patients with medically refractory absence epilepsy.
机译：目的：一部分患有儿童期和少年期癫痫病（CAE，JAE）的患者可能被归类为难治性患者。鉴于治疗此类患者的证据空白，据报道，该系列文献对该患者人群的迷走神经刺激（VNS）疗效进行了估算。方法：通过对2006年1月1日至2011年12月31日期间所有VNS接受者的图表回顾来鉴定患者。CAE和JAE的诊断基于常规标准。提取了人口统计学，癫痫现象学，管理和结果的详细信息。结果指标包括每日癫痫发作频率的减少（以VNS前癫痫发作频率的百分比衡量），并按国际抗癫痫联盟（ILAE）结果量表分类。结果：确定了9例患者（7例CAE，2例JAE），发作的平均年龄为5.4岁（±3.9）。发现VNS植入前的平均癫痫持续时间为3.9年（±1.4）。这些患者在接受手术治疗前中位数未使用5种抗癫痫药。在平均随访33.9个月（±25.5，最少4个月）后，有1名患者实现了完全癫痫发作（ILAE 1级），6例达到ILAE 4级，2例达到了ILAE 5级。发现每日癫痫发作频率的平均降低为53.5±60.3％（配对t检验的1面p值= 0.04），有50％的应答率为55.6％。结论：VNS可被视为难治性癫痫患者的治疗选择。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号