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首页> 外文期刊>Cerebrovascular diseases >Serial Measurement of Surface Expressions of CD63, P-Selectin and CD40 Ligand on Platelets in Atherosclerotic Ischemic Stroke. A Possible Role of CD40 Ligand on Platelets in Atherosclerotic Ischemic Stroke.
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Serial Measurement of Surface Expressions of CD63, P-Selectin and CD40 Ligand on Platelets in Atherosclerotic Ischemic Stroke. A Possible Role of CD40 Ligand on Platelets in Atherosclerotic Ischemic Stroke.

机译：在动脉粥样硬化性缺血性卒中血小板中CD63，P-选择蛋白和CD40配体表面表达的系列测量。 CD40配体在血小板中的可能作用在动脉粥样硬化性缺血性中风中。

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BACKGROUND: Platelet activation is a key step in the progression of atherosclerosis. The CD40 ligand (CD40L) on platelets may be a critical factor to develop the acute vascular events from atheroma. METHODS: To determine the role of CD40L on platelets in atherosclerotic ischemic stroke, we serially measured the expressions of CD63, P-selectin and CD40L on platelets in patients with atherosclerotic ischemic stroke (n = 25) and compared them with those in patients with asymptomatic carotid stenosis (n = 20) and in normal subjects (n = 24). RESULTS: The expressions of CD63 and P-selectin on platelets were significantly higher in patients with atherosclerotic ischemic stroke (n = 25) than in normal subjects (n = 24). The extents of surface expressions of CD63 and P-selectin on platelets showed no significant differences between atherosclerotic ischemic stroke and asymptomatic carotid stenosis. However, the CD40L expression on platelets was significantly higher in atherosclerotic ischemic stroke when compared to that in asymptomatic carotid stenosis. CONCLUSIONS: In our data, among the population with large artery atherosclerosis, the patients with symptomatic ischemic events showed a significantly elevated expression of CD40L on platelets compared to those without ischemic events. Therefore, the upregulation of CD40L on platelets may be a specific marker of platelet activation to provoke ischemic stroke from large artery atherosclerosis.
机译：背景：血小板活化是动脉粥样硬化进展的关键步骤。血小板上的CD40配体（CD40L）可能是导致动脉粥样硬化急性血管事件的关键因素。方法：为了确定CD40L在动脉粥样硬化性缺血性中风中血小板中的作用，我们连续测定了动脉粥样硬化性缺血性中风（n = 25）患者血小板中CD63，P-选择素和CD40L的表达，并将其与无症状的患者进行比较。颈动脉狭窄（n = 20）和正常人（n = 24）。结果：动脉粥样硬化性缺血性卒中患者（n = 25）的血小板中CD63和P-选择素的表达明显高于正常受试者（n = 24）。血小板上CD63和P-选择蛋白的表面表达程度在动脉粥样硬化性缺血性中风和无症状性颈动脉狭窄之间没有显着差异。然而，与无症状性颈动脉狭窄相比，在动脉粥样硬化性缺血性中风中血小板上的CD40L表达明显更高。结论：在我们的数据中，在有大动脉粥样硬化的人群中，有症状缺血事件的患者与无缺血事件的患者相比，其CD40L的表达明显升高。因此，血小板上CD40L的上调可能是血小板活化引起大动脉粥样硬化引起的缺血性中风的特异性标志物。

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