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首页> 外文期刊>International Journal for Vitamin and Nutrition Research: Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung >Combined effects of swim training and ginseng supplementation on exercise performance time, ROS, lymphocyte proliferation, and DNA damage following exhaustive exercise stress.
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Combined effects of swim training and ginseng supplementation on exercise performance time, ROS, lymphocyte proliferation, and DNA damage following exhaustive exercise stress.

机译：游泳训练和人参补充剂对力竭运动压力后的运动表现时间，ROS，淋巴细胞增殖和DNA损伤的综合影响。

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The purpose of this study was to analyze the combined effects of regular exercise and ginseng supplementation on peritoneal exudate ROS (reactive oxygen species), lymphocyte proliferation by splenocytes, and DNA damage following exhaustive exercise stress. Thirty-six female BALB/c mice were randomly divided into control (UT, n = 12), trained (TR, n = 12), and ginseng supplemented and trained (GT, n = 12) groups. Each group was divided into two equal subgroups where mice were studied at rest (UTre, TRre, and GTre) or immediately after exhaustive exercise stress (UTex, TRex, and GTex). Animals were bred in the animal facility, where they were housed at 22-24 degrees C and relative humidity (RH) 50-60% in a controlled environment with a 12-hour photoperiod, and provided food and water ad libitum. The trained mice underwent 10 weeks of endurance swim training (5 times/week) in water at 27-30 degrees C for 60 minutes. The analytical items examined were weight, proliferative activity, the production of ROS from peritoneal exudate cells, and DNA damage following exhaustive exercise stress (2 h exercise stress). Significant level was set at p < 0.05. The results obtained showed that the trained group had a significantly lower mean body weight than the untrained group (p < 0.05). However, there was no significant difference between UT and GT. Swim training increased swim survival time in TRex and GTex, and TRex showed the highest swim survival time. With regard to mitogenic activities of splenocytes in response to exhaustive exercise stress, all groups showed much lower lymphocyte proliferative activity when stimulated with media (Med), concanavalin A (ConA), or lipopolysaccharide (LPS) after exhaustive exercise stress. However, GTex had a higher proliferative activity than the other groups. Trained and ginseng-supplemented groups showed lower peritoneal ROS responses and lymphocyte DNA damage levels after exhaustive exercise. These findings suggest that the combined effect of swim training and ginseng supplementation sustain lymphocyte function in the presence of reduced ROS production and DNA damage following acute exercise stress.
机译：这项研究的目的是分析经常运动和人参补充剂对腹膜渗出运动后腹膜渗出液ROS（活性氧），脾细胞淋巴细胞增殖和DNA损伤的综合影响。将三十六只雌性BALB / c小鼠随机分为对照组（UT，n = 12），训练组（TR，n = 12）和人参补充组和训练组（GT，n = 12）。将每组分为两个相等的亚组，在其中研究小鼠的静止状态（UTre，TRre和GTre）或在力竭运动负荷后立即进行的小鼠（UTex，TRex和GTex）。将动物在动物设施中饲养，在那里将它们饲养在22-24摄氏度，相对湿度（RH）为50-60％的受控环境中，光照时间为12小时，并随意提供食物和水。训练有素的小鼠在水中在27-30摄氏度下进行了10周的耐力游泳训练（每周5次），持续60分钟。检查的分析项目是体重，增殖活性，腹膜渗出细胞产生ROS以及在力竭运动压力（2 h运动压力）后DNA损伤。显着水平设定为p <0.05。获得的结果表明，训练组的平均体重明显低于未训练组（p <0.05）。但是，UT和GT之间没有显着差异。游泳训练增加了TRex和GTex的游泳生存时间，而TRex显示了最长的游泳生存时间。关于脾脏细胞对力竭运动压力的有丝分裂活性，在力竭运动压力后，用培养基（Med），伴刀豆球蛋白A（ConA）或脂多糖（LPS）刺激时，所有组均显示低得多的淋巴细胞增殖活性。但是，GTex具有比其他组更高的增殖活性。经过训练和人参补充的组在力竭运动后显示出较低的腹膜ROS反应和淋巴细胞DNA损伤水平。这些发现表明，游泳训练和人参补充剂的联合作用在急性运动应激后，在ROS产生减少和DNA损伤减少的情况下，可维持淋巴细胞功能。

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