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首页> 外文期刊>International Journal for Vitamin and Nutrition Research: Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung >Risk of iron overload among middle-aged women.
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Risk of iron overload among middle-aged women.

机译：中年妇女铁过载的风险。

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摘要

Iron overload, expressed as increased body iron stores, has been recognized as a potential hazard because it promotes the generation of oxygen radicals. We analyzed factors associated with serum ferritin levels (an indicator of body iron stores) among middle-aged women with a high prevalence of nutrient supplement use. Serum ferritin concentrations were determined on automated immunoassay for 487 healthy women with the mean age of 57 years who participated in the New York University Women's Health Study. The mean serum ferritin concentration in postmenopausal women was more than twice that in premenopausal women. Serum ferritin concentrations progressively increased with advancing age, but adjustment for menopausal status considerably weakened this association. Among non-dietary factors, nonwhite ethnicity, obesity and cigarette smoking were positively associated with serum ferritin concentrations. After adjustment for these factors and for menopausal status, serum ferritin levels were positively associated with meat intake and multivitamin use and inversely associated with breakfast cereal consumption. However, none of these lifestyle factors positively associated with serum ferritin levels had a significant impact on serum ferritin levels above 100 ng/ml (approximately equal to median concentration). Our results suggest that iron overload seems unlikely among middle aged women through their diet and nutritional supplements.
机译：铁过载（表示为体内铁储备的增加）已被认为是潜在的危害，因为它促进了氧自由基的产生。我们分析了营养补充剂使用率高的中年女性与血清铁蛋白水平（体内铁存储指标）相关的因素。通过自动免疫测定法对参加纽约大学妇女健康研究的487名平均年龄为57岁的健康女性的血清进行了自动免疫测定。绝经后女性的平均血清铁蛋白浓度是绝经前女性的两倍以上。血清铁蛋白浓度随着年龄的增长而逐渐增加，但是更年期状态的调整大大削弱了这种联系。在非饮食因素中，非白人种族，肥胖和吸烟与血清铁蛋白浓度呈正相关。在对这些因素和更年期状况进行调整之后，血清铁蛋白水平与肉类摄入量和多种维生素的使用呈正相关，与早餐谷物的摄入呈负相关。然而，这些与血清铁蛋白水平呈正相关的生活方式因素均未对高于100 ng / ml（约等于中位数浓度）的血清铁蛋白水平产生显着影响。我们的研究结果表明，通过饮食和营养补充剂，中年女性似乎不太可能发生铁过载。

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