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首页> 外文期刊>Separation and Purification Technology >Combined UF-NF membrane system for filtering erythromycin fermentation broth and concentrating the filtrate to improve the downstream efficiency
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Combined UF-NF membrane system for filtering erythromycin fermentation broth and concentrating the filtrate to improve the downstream efficiency

机译：UF-NF联合膜系统用于过滤红霉素发酵液并浓缩滤液以提高下游效率

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摘要

This study developed an effective combined UF-NF membrane system for ultrafiltering erythromycin fermentation broth and concentrating the filtrate to improve the downstream efficiency. Three membranes with MWCO of 100, 30 and 10kDa respectively were tested for ultrafiltration work. 30kDa membrane was then selected due to its good performance by giving the highest permeation flux, satisfying permeate quality, high volume concentration factor (VCF=3.9) and high yield (98.9%). The optimal diafiltration factor (DF) for ultrafiltration is between 2.0 and 2.5. The basicity of UF permeate was found to be adverse to the NF concentration. At pH of 7-7.5, obvious enhancement of flux (>301/m~2 h) and VCF (about 4.0) were achieved for NF. NF concentrates can be extracted targeting erythromycin concentration of higher than 40,000 U/ml with good extraction efficiency, which is about 1.5% higher than that of filter press filtrate. With this technology, the usage of exacting solvent and de-emulsifler will be greatly minimized, reducing the load on the followed high speed centrifuge, solvent recycle and treatment of waste solids and wastewater. Moreover, NF permeates could be recycled directly as UF diafiltration water, extensively reducing the consumption of water and the load on wastewater treatment.
机译：本研究开发了一种有效的超滤-纳滤组合膜系统，用于超滤红霉素发酵液并浓缩滤液以提高下游效率。测试了三种膜的MWCO分别为100、30和10kDa的超滤工作。然后选择30kDa的膜，因为它具有良好的性能，可提供最高的渗透通量，满足渗透质量，高体积浓缩系数（VCF = 3.9）和高收率（98.9％）。超滤的最佳渗滤系数（DF）在2.0到2.5之间。发现UF渗透液的碱性对NF浓度不利。在7-7.5的pH值下，NF的通量（> 301 / m〜2 h）和VCF（约4.0）明显增加。 NF浓缩液可针对红霉素浓度高于40,000 U / ml的情况进行提取，且提取效率高，比压滤机滤液高约1.5％。借助这项技术，可以极大地减少严格的溶剂和反乳化剂的使用，从而减少了随后的高速离心机，溶剂循环以及废物固体和废水处理的负荷。此外，NF渗透物​​可以作为UF渗滤水直接回收利用，从而大大减少了水的消耗和废水处理的负担。

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