Conditional animal models: a strategy to define when oncogenes will be effective targets to treat cancer.

Giuriato S; Rabin K; Fan AC; Shachaf CM; Felsher DW

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Conditional animal models: a strategy to define when oncogenes will be effective targets to treat cancer.

机译：有条件的动物模型：一种定义癌基因何时将成为治疗癌症的有效靶点的策略。

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The ability to model cancer in the mouse has provided a robust methodology to dissect the molecular etiology of cancer. These models serve as potentially powerful platforms to preclinically evaluate novel therapeutics. In particular, the recent development of strategies to conditionally induce the or knockout the function of genes in a tissue specific manner has enabled investigators to engineer mice to demonstrate that the targeted inactivation of specific oncogenes can be effective in inducing sustained regression of tumors. Thus, these animal models will be useful to define the specific genes that will be therapeutically useful to target for the treatment of particular human cancers.

机译：在小鼠中建模癌症的能力提供了一种强有力的方法来剖析癌症的分子病因。这些模型可作为潜在强大的平台，以在临床前评估新型疗法。特别地，以组织特异性方式有条件地诱导基因功能或敲除基因功能的策略的最新发展使研究人员能够对小鼠进行工程改造，以证明特定致癌基因的靶向失活可以有效地诱导肿瘤的持续消退。因此，这些动物模型将有助于定义特定的基因，这些基因对于靶向治疗特定的人类癌症具有治疗作用。

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来源
《Seminars in cancer biology》 |2004年第1期|共9页
作者
Giuriato S; Rabin K; Fan AC; Shachaf CM; Felsher DW;
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正文语种 eng
中图分类肿瘤学;
关键词
Models; Animal; Neoplasms; Oncogenes; 肿瘤; 癌基因;

机译：Models;Animal;Neoplasms;Oncogenes;肿瘤;癌基因;

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1. Conditional animal models: a strategy to define when oncogenes will be effective targets to treat cancer. [J] . Giuriato S, Rabin K, Fan AC, Seminars in cancer biology . 2004,第1期

机译：有条件的动物模型：一种定义癌基因何时将成为治疗癌症的有效靶点的策略。
2. A human cancer xenograft model utilizing normal pancreatic duct epithelial cells conditionally transformed with defined oncogenes [J] . Yuki Inasawa, Kenji Yamada, TakasM Yugawa Carcinogenesis . 2014,第8期

机译：利用正常胰腺导管上皮细胞有条件地转化特定癌基因的人类癌症异种移植模型
3. A human cancer xenograft model utilizing normal pancreatic duct epithelial cells conditionally transformed with defined oncogenes [J] . Yuki Inasawa, Kenji Yamada, TakasM Yugawa Carcinogenesis . 2014,第8期

机译：利用正常的胰腺导管上皮细胞有条件地转化，用定义的甲基化剂转化的人癌异种移植模型
4. POTENTIALS FOR SiRNA NANOCAPSULES TARGETED AGAINST THE JONCTION POINT OF THEEWS-Fli 1 ONCOGENE: EWING' SARCOMA AS A MODEL [C] . Nedjma Toub, Jean-Rémi Bertrand, Claude Malvy, Annual meeting exposition of the Controlled Release Society . 2005

机译：针对THEEWS-Fli 1癌基因的结合点定位的SiRNA纳米囊的潜力：作为模型的伊文氏肉瘤
5. Targeted Degradation of the MYC Oncogene Using PP2A-B56alpha Selective Small Molecule Modulators of Proteinphosphatase 2A as a Therapeutic Strategy for Treating Myc-Driven Cancers [D] . Farrington, Caroline C. 2020

机译：使用PP2A-B56α选择性小分子调节剂的蛋白质磷酸酶2a的靶向降解Myc癌基因作为治疗Myc驱动癌症的治疗策略
6. Predictive computational modeling to define effective treatment strategies for bone metastatic prostate cancer [O] . Leah M. Cook, Arturo Araujo, Julio M. Pow-Sang, -1

机译：预测性计算模型来定义骨转移性前列腺癌的有效治疗策略
7. Tideland Animal AR: Superimposing 3D Animal Models to User Defined Targets for Augmented Reality Game [O] . Youngo Lee, Jongmyong Choi 2014

机译：Tideland Animal AR：将3D动物模型叠加到增强现实游戏的用户定义目标上
8. RNASEH2A -- a Putative Non-Oncogene Addiction Gene Target and Marker for Radiosensitivity in High Risk Prostate Cancer. [R] . E. M. Schaeffer Z. Huang 2013

机译：RNasEH2a - 一种推定的非致癌基因成瘾基因靶标和高危前列腺癌放射敏感性标记物。

Conditional animal models: a strategy to define when oncogenes will be effective targets to treat cancer.

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