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首页> 外文期刊>Sexually transmitted diseases >Rapidly increasing prevalence of HIV and syphilis and HIV-1 subtype characterization among men who have sex with men in Jiangsu, China.
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Rapidly increasing prevalence of HIV and syphilis and HIV-1 subtype characterization among men who have sex with men in Jiangsu, China.

机译：中国江苏省与男性发生性行为的男性中HIV和梅毒的流行迅速增加，HIV-1亚型的特征也有所增加。

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OBJECTIVES: To investigate the prevalence of HIV, hepatitis B (HBV), hepatitis C (HCV), and syphilis among men who have sex with men (MSM) in 2 cities of Jiangsu, China, and to characterize the HIV-1 subtypes prevalent among this population. METHODS: During September 2006 and July 2007, 296 and 173 MSM were recruited from Nanjing and Yangzhou, respectively. Sera samples were collected and tested for HIV, HBV, HCV, and syphilis infections. The nucleotide sequences of p17 and C2V3 regions were determined by RT-nested-PCR and sequencing. HIV-1 subtypes were characterized by phylogenetic analysis. RESULTS: The prevalence of HIV, HBV, HCV, and syphilis infections among MSM was 5.8%, 11.1%, 0.7%, and 27.7%, respectively. The prevalence of HIV and syphilis was significantly higher in 2006-2007 than in 2003 (P 0.05). The phylogenetic tree of p17 showed that HIV-1 subtypes B, CRF01_AE, and CRF07_BC accounted for 35.7%, 35.7%, and 28.6%, respectively. The result of C2V3 showed that 45.5%, 36.4%, and 18.2% sequences belonged to HIV-1 subtype B, CRF01_AE, and BC recombinants, respectively. The subtype characterization in Jiangsu was significantly different from those in Beijing (P <0.05). Furthermore, Jiangsu HIV-1 B strains were different from majority of China B' strains and originated from Beijing. CONCLUSIONS: The rapidly increasing prevalence and complex subtypes of HIV-1 suggest that effective prevention and intervention strategies are urgently needed for MSM in Jiangsu.
机译：目的：调查江苏省两个城市与男性发生性关系的男性中艾滋病毒，乙型肝炎（HBV），丙型肝炎（HCV）和梅毒的患病率，并鉴定流行的HIV-1亚型在这个人群中。方法：2006年9月和2007年7月，分别从南京和扬州招募了296名和173名MSM。收集血清样本并测试其是否感染HIV，HBV，HCV和梅毒。通过RT-巢式PCR和测序确定p17和C2V3区域的核苷酸序列。 HIV-1亚型通过系统发育分析进行表征。结果：MSM中HIV，HBV，HCV和梅毒感染的患病率分别为5.8％，11.1％，0.7％和27.7％。 2006-2007年，江苏省的HIV和梅毒患病率明显高于2003年（P <或= 0.0013），高于中国其他地区（P <或= 0.003）。相反，目前的研究与2003年的研究相比，HBV和HCV的患病率没有显着差异（P> 0.05）。 p17的系统发育树显示，HIV-1亚型B，CRF01_AE和CRF07_BC分别占35.7％，35.7％和28.6％。 C2V3的结果表明，分别有45.5％，36.4％和18.2％的序列属于HIV-1亚型B，CRF01_AE和BC重组体。江苏的亚型特征与北京明显不同（P <0.05）。此外，江苏HIV-1 B毒株与大多数中国B'毒株不同，起源于北京。结论：HIV-1的快速流行和复杂亚型表明，江苏省MSM迫切需要有效的预防和干预策略。

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