Investigating Nonribosomal Peptide and Polyketide Biosynthesis by Direct Detection of Intermediates on > 70 kDa Polypeptides by Using Fourier-Transform Mass Spectrometry

Leslie M.Hicks; Matthew T.Mazur; Leah M.Miller; Pieter C.Dorrestein; Nathan A.Schnarr

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Investigating Nonribosomal Peptide and Polyketide Biosynthesis by Direct Detection of Intermediates on > 70 kDa Polypeptides by Using Fourier-Transform Mass Spectrometry

机译：通过使用傅里叶变换质谱法直接检测> 70 kDa多肽上的中间体来研究非核糖体肽和聚酮化合物的生物合成

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"Soft" ionization methods,such as electrospray ionization (ESI) and matrix-assisted laser desorption ionization (MALDI),have revolutionized the field of mass spectrometry (MS) by enabling the transfer of intact macromolecules from solution to the gas phase.Continuing advances and refinements of ion sources coupled with various mass analyzers have translated to an ability to investigate ever more complex biological systems including high-mass species and macromolecular assemblies.

机译：“软”电离方法，例如电喷雾电离（ESI）和基质辅助激光解吸电离（MALDI），通过使完整的大分子从溶液转移到气相，彻底改变了质谱（MS）领域。离子源的完善和与各种质量分析仪的结合，使人们有能力研究更加复杂的生物系统，包括高质量物种和大分子组装体。

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来源
《Chembiochem: A European journal of chemical biology》 |2006年第6期|共4页
作者
Leslie M.Hicks; Matthew T.Mazur; Leah M.Miller; Pieter C.Dorrestein; Nathan A.Schnarr;
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原文格式 PDF
正文语种 eng
中图分类生物化学;
关键词
biosynthesis; Fourier-transform mass spectrometry; nonribosomal peptide synthesis; polyketides; protein modifications;

机译：生物合成;傅立叶变换质谱;非核糖体肽合成;聚酮;蛋白质修饰;

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1. Investigating Nonribosomal Peptide and Polyketide Biosynthesis by Direct Detection of Intermediates on > 70 kDa Polypeptides by Using Fourier-Transform Mass Spectrometry [J] . Leslie M.Hicks, Matthew T.Mazur, Leah M.Miller, Chembiochem: A European journal of chemical biology . 2006,第6期

机译：通过使用傅里叶变换质谱法直接检测> 70 kDa多肽上的中间体来研究非核糖体肽和聚酮化合物的生物合成
2. Nostophycin Biosynthesis Is Directed by a Hybrid Polyketide Synthase-Nonribosomal Peptide Synthetase in the Toxic Cyanobacterium Nostoc sp. Strain 152 [J] . David P. Fewer, Julia ?sterholm, Leo Rouhiainen, Applied Microbiology . 2011,第22期

机译：Nostophycin的生物合成是由有毒蓝藻Nostoc sp。中的杂合聚酮化合物合酶-非核糖体肽合成酶指导的。 152号
3. Polyketide Chain Skipping Mechanism in the Biosynthesis of the Hybrid Nonribosomal Peptide-Polyketide Antitumor Antibiotic Leinamycin in Streptomyces atroolivaceus S-140 [J] . Gong-Li Tang, Yi-Qiang Cheng, Ben Shen Journal of natural products . 2006,第3期

机译：Atroolivaceus S-140杂合非核糖体多肽-聚酮类抗肿瘤抗生素莱那霉素生物合成中的聚酮化合物跳链机理。
4. MASS SPECTROMETRIC ANALYSIS OF POLYKETIDE BIOSYNTHESIS: FTICR-MS VERSUS LOW-RESOLUTION LC-MS FOR ANALYSIS OF ACTIVE-SITE BOUND INTERMEDIATES [C] . Christopher M. Rath, Shilah Bonnet, Kevin Renoylds, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2009

机译：聚酮化合物生物合成的质谱分析：FTICR-MS与低分辨率LC-MS分析，用于分析有源点结合的中间体
5. Active site mapping of iterative polyketide synthases and the detection of polyketide intermediates using high-resolution Fourier transform mass spectrometry. [D] . Meehan, Michael Jospeh. 2009

机译：迭代聚酮化合物合成酶的活性位点图谱和使用高分辨率傅里叶变换质谱法检测聚酮化合物中间体的位置。
6. Nostophycin Biosynthesis Is Directed by a Hybrid Polyketide Synthase-Nonribosomal Peptide Synthetase in the Toxic Cyanobacterium Nostoc sp. Strain 152 [O] . David P. Fewer, Julia Österholm, Leo Rouhiainen, 2011

机译：Nostophycin生物合成是由有毒蓝藻Nostoc sp。中的杂合聚酮化合物合酶-非核糖体肽合成酶指导的。应变152
7. Nostophycin Biosynthesis Is Directed by a Hybrid Polyketide Synthase-Nonribosomal Peptide Synthetase in the Toxic Cyanobacterium Nostoc sp. Strain 152▿† [O] . Fewer, David P., Österholm, Julia, Rouhiainen, Leo, 2011

机译：Nostophycin生物合成是由有毒蓝藻Nostoc sp。中的杂合聚酮化合物合酶-非核糖体肽合成酶指导的。应变152▿†
8. Detection of Mass 16241 Ions by Fourier-Transform Mass Spectrometry [R] . Amster, I. J., McLafferty, F. W., Castro, M. E., 1986

机译：傅立叶变换质谱法检测质量16241离子

Investigating Nonribosomal Peptide and Polyketide Biosynthesis by Direct Detection of Intermediates on > 70 kDa Polypeptides by Using Fourier-Transform Mass Spectrometry

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