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首页> 外文期刊>Skin research and technology: official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) >Development and characterization of a human dermal equivalent with physiological mechanical properties.
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Development and characterization of a human dermal equivalent with physiological mechanical properties.

机译：具有生理机械特性的人体真皮等效物的开发和表征。

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摘要

Different models of reconstructed skin are available, either to provide skin wound healing when this process is deficient, or to be used as an in vitro model. Nevertheless, few studies have focused on the mechanical properties of skin equivalent. Indeed, human skin is naturally under tension. Taking into account these features, the purpose of this work was to obtain a cellularized dermal equivalent (CDE), composed of collagen and dermal fibroblasts.To counteract the natural retraction of CDE and to maintain it under tension, different biomaterials were tested. Selection criteria were biocompatibility, bioadhesion properties, ability to induce differentiation of fibroblasts into myofibroblasts and mechanical characterization, considering that of skin in vivo. These assays led to the selection of honeycomb of polyester. CDE constructed on this biomaterial was further characterized mechanically using tensile tests.The results showed that mechanical features of the obtained dermal equivalent, including myofibroblasts, were similar to skin in vivo.The original model of dermal equivalent presented herein may be a useful tool for clinical use and as an in vitro model for toxicological/pharmacological research.
机译：可以使用不同的重建皮肤模型，以在此过程不足时提供皮肤伤口愈合，或用作体外模型。然而，很少有研究集中在皮肤等效物的机械性能上。确实，人类皮肤自然处于紧张状态。考虑到这些特征，这项工作的目的是获得由胶原蛋白和真皮成纤维细胞组成的细胞化真皮等效物（CDE）。为抵消CDE的自然收缩并使其保持张力，我们测试了多种生物材料。选择标准是生物相容性，生物粘附特性，诱导成纤维细胞分化为成肌纤维细胞的能力和机械特性（考虑到体内皮肤）。这些测定导致聚酯蜂窝的选择。在生物材料上构建的CDE通过拉伸试验进行了机械表征，结果表明所获得的真皮等效物（包括成肌纤维细胞）的机械特征与体内皮肤相似。本文介绍的真皮等效物的原始模型可能是临床上有用的工具用作毒理学/药理学研究的体外模型。

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