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首页> 外文期刊>ORL: Journal for oto-rhino-laryngology and its borderlands >Decreased measles virus-neutralizing activity in sera from otosclerotic patients.
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Decreased measles virus-neutralizing activity in sera from otosclerotic patients.

机译：耳硬化患者血清中的麻疹病毒中和活​​性降低。

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HYPOTHESIS: Any kind of depressed systemic anti-measles reaction can lead to the induction of a local immune response in the inner ear and possibly to reactivation of bone turnover in this region. METHODS: Different dilutions of sera were tested for neutralizing activity against a constant viral concentration. The ability of measles virus to infect and replicate in the cell monolayer was detected by enumeration of living and growing cells with a colored reaction. RESULTS: Virus-neutralizing activity in the sera of patients with confirmed otosclerosis was significantly weaker than in that of healthy controls. When age- and sex-matched pairs were compared, the neutralizing activity in the healthy counterpart was higher in 5 cases. Nearly complete viral neutralization was achieved with samples containing inactivated complement and in IgG-containing fractions, but not in immunoglobulin-depleted samples. CONCLUSION: The present study is consistent with measles virus participation at least in the initiation of some cases of otosclerosis.
机译：假设：任何一种沮丧的全身性麻疹反应都会导致内耳局部免疫反应的诱导，并可能导致该区域骨更新的重新激活。方法：测试了不同稀释度的血清对恒定病毒浓度的中和活性。麻疹病毒在细胞单层中感染和复制的能力通过对有色和有反应的活细胞和正在生长的细胞进行计数来检测。结果：确诊耳硬化症患者血清中的病毒中和活​​性明显弱于健康对照者。比较年龄和性别匹配的配对时，健康配对者的中和活性在5例中更高。含有灭活补体的样品和含IgG的组分几乎实现了病毒的中和，但免疫球蛋白耗竭的样品则没有。结论：本研究与麻疹病毒的参与至少在某些耳硬化症病例中是一致的。

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