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首页> 外文期刊>Advances in oto-rhino-laryngology >Antimeasles immunoglobulin G and virus-neutralizing activity in sera of patients with otosclerosis.
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Antimeasles immunoglobulin G and virus-neutralizing activity in sera of patients with otosclerosis.

机译：耳硬化症患者血清中的无定形虫免疫球蛋白G和病毒中和活​​性。

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Otosclerosis is considered as an organ-specific measles virus (MV)-induced disease. The majority of people are infected with MV during childhood, and the immune activation is characterized by a lifelong persistence. Any kind of depressed systemic antimeasles reaction can lead to induction of a local immune response in the inner ear. MV proteins were resolved by conventional polyacrylamide gel electrophoresis in the presence of a denaturing detergent. In subsequent Western blot, healthy blood donors demonstrated a stronger reaction against most proteins than age- and sex-matched otosclerotic patients. Different serum dilutions were tested for neutralizing activity against constant MV concentration. Nearly complete viral neutralization was achieved with samples containing inactivated complement and in immunoglobulin-G-containing fractions, and activity in sera from patients with confirmed otosclerosis was significantly weaker than in healthy individuals. Our observations are consistent with viral participation in otosclerotic pathogenesis, but it is difficult to say if the diminished antimeasles humoral response is a consequence of or the cause for a local measles infection.
机译：耳硬化症被认为是器官特异性麻疹病毒（MV）诱发的疾病。大多数人在童年时期就感染了MV，并且免疫激活的特征是终身坚持不懈。任何形式的系统性手足压抑反应都会导致内耳局部免疫反应的诱导。在变性去污剂存在下，通过常规的聚丙烯酰胺凝胶电泳分离MV蛋白。在随后的蛋白质印迹中，健康献血者显示出对大多数蛋白质的反应要强于年龄和性别相匹配的耳硬化症患者。测试了不同的血清稀释液对恒定MV浓度的中和活性。含有灭活的补体和含免疫球蛋白-G的组分的样品可实现近乎完全的病毒中和，确诊的耳硬化症患者的血清活性明显弱于健康个体。我们的观察结果与病毒参与耳硬化病的发病机理是一致的，但是很难说出减少的无脚humor体液反应是局部麻疹感染的结果还是其原因。

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