...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Modern rheumatology >Anti-neutrophil cytoplasmic autoantibodies against bactericidal/permeability-increasing protein in patients with rheumatoid arthritis and their correlation with bronchial involvement.
【24h】

Anti-neutrophil cytoplasmic autoantibodies against bactericidal/permeability-increasing protein in patients with rheumatoid arthritis and their correlation with bronchial involvement.

机译：类风湿关节炎患者抗细菌/通透性增加蛋白的抗中性粒细胞胞浆自身抗体及其与支气管受累的关系。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Anti-neutrophil cytoplasmic autoantibodies against bactericidal/permeability-increasing protein (BPI-ANCA) are known to be present in patients with cystic fibrosis, diffuse panbronchiolitis, and inflammatory bowel disease, especially in relation to chronic Gram-negative bacterial infection. To investigate the possible role of BPI-ANCA in rheumatoid arthritis (RA), we measured the serum titer of BPI-ANCA and examined clinical manifestations, including pulmonary complications, in patients with RA. Seventy-four RA patients were recruited to our study. The titer of BPI-ANCA was measured by enzyme-linked immunosorbent assay (ELISA). Pulmonary complications were evaluated using high-resolution computed tomography (HRCT), which revealed 26 patients with bronchial diseases (BD group), 25 with interstitial pneumonia (IP group), and 23 without any particular lung lesion (normal group). The correlations between the titer of BPI-ANCA and patients' clinical and laboratory findings were then analyzed. The numbers of tender joints, swollen joints, and the Disease Activity Score including 28 joint count were significantly higher in the BD group. The titer of BPI-ANCA was positively correlated with age, erythrocyte sedimentation rate (ESR), and bronchial involvement in all subjects. Stepwise multiple regression analysis of factors affecting the titer of BPI-ANCA selected ESR and bronchial involvement as independent variables. Our results show that BPI-ANCA was positively correlated with chronic inflammatory status in RA patients, and we is believe it is positively linked with bronchial diseases.
机译：已知在患有囊性纤维化，弥漫性全细支气管炎和炎症性肠病的患者中，尤其是与慢性革兰氏阴性细菌感染有关的患者中，存在抗杀菌/通透性增强蛋白（BPI-ANCA）的抗中性粒细胞胞质自身抗体。为了研究BPI-ANCA在类风湿关节炎（RA）中的可能作用，我们测量了BPI-ANCA的血清滴度并检查了RA患者的临床表现，包括肺部并发症。研究共招募了74名RA患者。 BPI-ANCA的滴度通过酶联免疫吸附试验（ELISA）测定。使用高分辨率计算机断层扫描（HRCT）对肺部并发症进行评估，结果显示26例支气管疾病患者（BD组），25例间质性肺炎（IP组）和23例无任何特殊肺病变的患者（正常组）。然后分析了BPI-ANCA滴度与患者临床和实验室检查结果之间的相关性。 BD组的嫩关节数，肿胀数和包括28个关节数在内的疾病活动评分均明显高于BD组。在所有受试者中，BPI-ANCA的滴度与年龄，红细胞沉降率（ESR）和支气管受累呈正相关。影响BPI-ANCA滴度的因素的逐步多元回归分析选择ESR和支气管受累为自变量。我们的结果表明，BPI-ANCA与RA患者的慢性炎症状态呈正相关，我们相信它与支气管疾病呈正相关。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号