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首页> 外文期刊>Modern rheumatology >Successful management of systemic lupus erythematosus nephritis flare-up during pregnancy with tacrolimus.
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Successful management of systemic lupus erythematosus nephritis flare-up during pregnancy with tacrolimus.

机译：他克莫司在妊娠期成功治疗系统性红斑狼疮肾炎发作。

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摘要

Systemic lupus erythematosus (SLE) is one of the common autoimmune disorders that affect women during their childbearing years. Disease activity frequently increases during pregnancy and the postpartum period, representing a challenge for both the patient and the treating physician(s). We report a case of successful management of lupus nephritis flare in the first trimester. The patient developed bilateral leg edema and nephrotic-range proteinuria of 5 g/day. She was treated with steroids and tacrolimus, which resulted in the induction of remission during pregnancy. The patient reached full-term with no maternal or fetal complications. This case indicates that tacrolimus, which is convenient to use and has limited adverse effects, may represent a potential safe and effective treatment option for SLE nephritis during pregnancy.
机译：系统性红斑狼疮（SLE）是影响妇女生育年龄的常见自身免疫性疾病之一。在怀孕期间和产后期间，疾病活动频繁增加，这对患者和主治医生均构成挑战。我们报告在头三个月成功治疗狼疮性肾炎发作的病例。该患者出现双侧腿浮肿和5 g /天的肾病范围蛋白尿。她接受了类固醇和他克莫司治疗，导致怀孕期间缓解。该患者足月无母婴并发症。该病例表明，他克莫司使用方便且不良反应有限，可能代表妊娠期SLE肾炎的潜在安全有效治疗选择。

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