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首页> 外文期刊>Modern rheumatology >A case of ANCA-negative renal small-vessel vasculitis with tubulointerstitial infiltration of IgG4-positive plasma cells
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A case of ANCA-negative renal small-vessel vasculitis with tubulointerstitial infiltration of IgG4-positive plasma cells

机译：ANCA阴性肾小血管炎伴肾小管间质浸润IgG4阳性浆细胞

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摘要

A 62-year-old male patient presented with progressive renal dysfunction for 2 months. He had elevated serum C-reactive protein and IgG4 levels with absence of anti-neutrophil cytoplasmic antibodies. A renal biopsy showed severe tubulointerstitial nephritis (TIN) with extensive infiltration of IgG4-positive plasma cells, suggesting a diagnosis of IgG4-related kidney disease (IgG4-RKD). However, the identification of a few crescentic glomeruli and necrotizing vasculitis of an interlobular artery lead to a diagnosis of renal small-vessel vasculitis. This case indicates that a careful examination is required to distinguish between IgG4-RKD and TIN caused by renal small-vessel vasculitis.
机译：一名62岁的男性患者出现进行性肾功能不全2个月。在没有抗中性粒细胞胞浆抗体的情况下，他的血清C反应蛋白和IgG4水平升高。肾脏活检显示严重的肾小管间质性肾炎（TIN），并广泛浸润IgG4阳性浆细胞，提示诊断为IgG4相关的肾脏疾病（IgG4-RKD）。然而，鉴定一些小叶新月型肾小球和小叶间动脉坏死性血管炎可诊断为肾小血管性脉管炎。这种情况表明需要仔细检查，以区分由肾小血管血管炎引起的IgG4-RKD和TIN。

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