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Population-based approaches to genetics of migraine

机译:基于人群的偏头痛遗传学方法

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Background While the most accurate diagnosis of migraine typically requires a clinical interview guided by strict diagnostic criteria, an alternative approach that ascertains migraine by questionnaire in population-based settings has been instrumental in the discovery of common genetic variants influencing migraine risk. This result may be surprising. Population-based approaches are often criticized for limited ability to distinguish migraine from other forms of primary headache. It is thus useful to revisit prevailing ideas about population-based ascertainment of migraine to evaluate the extent to which this approach has potential for additional insights into migraine genetics and therefore pathophysiology.
机译:背景技术虽然最准确的偏头痛诊断通常需要在严格的诊断标准的指导下进行临床访谈,但在以人群为基础的环境中通过问卷调查确定偏头痛的另一种方法已有助于发现影响偏头痛风险的常见遗传变异。这个结果可能令人惊讶。人们常常批评基于人群的方法将偏头痛与其他形式的原发性头痛区别开来的能力有限。因此,有必要重新审视有关基于人群的偏头痛确诊的主流观点,以评估这种方法在多大程度上可以进一步了解偏头痛的遗传学和病理生理学。

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