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首页> 外文期刊>Spectrochimica acta, Part A. Molecular and biomolecular spectroscopy >Study on fluorescence property of carvedilol and determination of carvedilol by fluorimetry
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Study on fluorescence property of carvedilol and determination of carvedilol by fluorimetry

机译：卡维地洛的荧光特性研究及荧光法测定卡维地洛

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摘要

The property of carvedilol in acid-alkaline medium was studied by spectrofluorimetry. Effects of organic solvents on carvedilol fluorescence spectra were examined and the reason was discussed. A simple, rapid and high sensitive fluorimetric method for the determination of carvedilol in medicine is developed. The measurement of relative fluorescence intensity was carried out at 356 nm with excitation at 254 nm. Effects of pH, standing time and foreign ions on the determination of carvedilol have been examined. A linear relationship was obtained between the relative fluorescence intensity and concentration of carvedilol in the range of 0.50-270 ng ml(-1). The linear regression equation of the calibration graph is C = 0.000543F - 0.002 (C is concentration (mug ml(-1)) and F is relative fluorescence intensity in the equation), with a correlation coefficient of linear regression of 0.9998 and relative standard deviation of 2.31%. The detection limit of this method is 0.19 ng ml(-1), and recovery is from 98.70 to 102.1%. This method can be used for determination of carvedilol in tablet. The results obtained by this method agreed with those by the official method. (C) 2004 Elsevier B.V. All rights reserved.
机译：通过荧光光谱法研究了卡维地洛在酸性碱性介质中的性质。研究了有机溶剂对卡维地洛荧光光谱的影响，并讨论了原因。建立了一种简便，快速，高灵敏度的荧光法测定药物中卡维地洛的含量。相对荧光强度的测定在356nm下在254nm下激发。研究了pH，停留时间和外来离子对卡维地洛测定的影响。卡维地洛的相对荧光强度与浓度之间的线性关系在0.50-270 ng ml（-1）之间。校正图的线性回归方程为C = 0.000543F-0.002（C为浓度（杯子ml（-1）），方程中F为相对荧光强度），线性回归的相关系数是0.9998，相对标准品偏差为2.31％。该方法的检出限为0.19 ng ml（-1），回收率为98.70至102.1％。该方法可用于测定片剂中卡维地洛的含量。通过这种方法获得的结果与通过官方方法得出的结果一致。 （C）2004 Elsevier B.V.保留所有权利。

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