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首页> 外文期刊>Spectrochimica acta, Part A. Molecular and biomolecular spectroscopy >Resonance Rayleigh scattering study of interaction of heparin with some cationic surfactants and their analytical application
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Resonance Rayleigh scattering study of interaction of heparin with some cationic surfactants and their analytical application

机译：肝素与某些阳离子表面活性剂相互作用的共振瑞利散射研究及其分析应用

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摘要

Binding of heparin with a cationic surfactant such as cetyldimethyl benzylammonium chloride (CDBAC), tetradecyldimethyl benzylammonium chloride (Zeph), cetylpyridinium bromide (CPB), tetradecane pyridinium bromide (TPB) and cetyltrimethylammonium bromide (CTAB) in a near-neutral medium can result in a significant enhancement of resonance Rayleigh scattering (RRS) intensities. The results showed that the reaction conditions and RRS spectral characteristics of these reactions are similar, but their sensitivities are obviously different. Among them, the sensitivity of CDBAC with an aryl and large molecular weight is the highest, while that of CTAB without aryl and with small molecular weight is the lowest. The detection limit for heparin of the former is I I ng ml(-1) while that of the latter is 33 ng ml(-1). The method has better selectivity and was applied to the determination of trace amounts of heparin in sodium heparin injection samples with satisfactory results. Furthermore, it is discovered that the RRS intensity is related to the structure and molecular weight of the cationic surfactant. (C) 2004 Elsevier B.V. All rights reserved.
机译：肝素在近中性培养基罐中与阳离子表面活性剂的结合，例如十六烷基二甲基苄基氯化铵（CDBAC），十四烷基二甲基苄基氯化铵（Zeph），十六烷基溴化吡啶鎓（CPB），十四烷溴化吡啶鎓（TPB）和十六烷基三甲基溴化铵（CTAB）共振瑞利散射（RRS）强度的显着提高。结果表明，这些反应的反应条件和RRS光谱特征相似，但灵敏度差异明显。其中，具有芳基和大分子量的CDBAC的灵敏度最高，而没有芳基和具有小分子量的CTAB的灵敏度最低。前者肝素的检出限为I ng ml（-1），后者为33 ng ml（-1）。该方法具有较好的选择性，可用于肝素钠注射液中痕量肝素的测定，结果令人满意。此外，发现RRS强度与阳离子表面活性剂的结构和分子量有关。 （C）2004 Elsevier B.V.保留所有权利。

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