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首页> 外文期刊>Surgical Endoscopy >Day-to-day discrepancy in Bravo pH monitoring is related to the degree of deterioration of the lower esophageal sphincter and severity of reflux disease.
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Day-to-day discrepancy in Bravo pH monitoring is related to the degree of deterioration of the lower esophageal sphincter and severity of reflux disease.

机译：Bravo pH监测中的日常差异与食管下括约肌的恶化程度和反流疾病的严重程度有关。

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BACKGROUND: The Bravo capsule allows monitoring of esophageal acid exposure over a two-day period. Experience has shown that 24-32% of patients will have abnormal esophageal acid exposure detected on only one of the 2 days monitored. This variation has been explained by the effect of endoscopy and sedation. The aim of this study was to assess the day-to-day discrepancy following transnasal placement of the Bravo capsule without endoscopy or sedation and to determine factors related to this variability. METHODS: Bravo pH monitoring was performed by transnasal placement of the capsule in 310 patients. Patients were divided into groups based on the composite pH score: both days normal, both days abnormal and only one of the 2 days abnormal. Lower esophageal sphincter (LES) characteristics were compared between groups. RESULTS: Of the 310 patients evaluated, 60 (19%) showed a discrepancy between the 2 days. A total of 127 patients had a normal pH score on both days and 123 had an abnormal pH score on both days. Of the 60 patients with a discrepancy, 27 were abnormal the first day and 33 (55%) were abnormal the second day. Patients with abnormal esophageal acid exposure on both days had higher degrees of esophageal acid exposure and were more likely to have a defective LES compared to those with an abnormal score on only one day (35 vs. 83%, p=0.027). CONCLUSION: Patients with a discrepancy between days of Bravo pH monitoring have lower esophageal acid exposure. Variability between the 2 days represents early deterioration of the gastroesophageal barrier and indicates less advanced reflux disease.
机译：背景：Bravo胶囊允许在两天内监测食道酸暴露。经验表明，仅在所监测的2天之一中检测到24-32％的患者食道酸暴露异常。内窥镜检查和镇静作用可以解释这种差异。这项研究的目的是评估鼻腔内放置Bravo胶囊后无内镜或镇静作用的每日差异，并确定与这种变异性相关的因素。方法：通过310名患者的鼻腔放置胶囊进行Bravo pH监测。根据综合pH值将患者分为两组：正常两天，异常两天和仅异常两天之一。比较各组食管下括约肌（LES）的特征。结果：在所评估的310例患者中，有60例（19％）在两天之间显示出差异。共有127例患者的pH值在两天内均正常，而123例患者的pH值在两天内均异常。在有差异的60例患者中，第一天异常27例，第二天异常33例（55％）。与只有一天异常评分的患者相比，这两天食管酸暴露异常的患者的食管酸暴露程度更高，并且LES缺陷的可能性更高（35 vs. 83％，p = 0.027）。结论：在Bravo pH监测的几天之间存在差异的患者具有较低的食管酸暴露。 2天之间的差异表示胃食管屏障的早期恶化，并表示晚期反流疾病较少。

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