...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Surgical Endoscopy >Persistent elevation of plasma vascular endothelial growth factor levels during the first month after minimally invasive colorectal resection.
【24h】

Persistent elevation of plasma vascular endothelial growth factor levels during the first month after minimally invasive colorectal resection.

机译：微创结直肠癌切除术后第一个月血浆血管内皮生长因子水平持续升高。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

BACKGROUND: Elevations of plasma vascular endothelial growth factor (VEGF) have been noted early after colorectal resection. The duration of this increase is unknown. Because VEGF is a potent promoter of angiogenesis, which is critical to tumor growth, a sustained increase in blood VEGF levels after surgery may stimulate the growth of residual metastases early after surgery. This preliminary study aimed to determine VEGF levels during the first month after colorectal resection. METHODS: Patients from three prospective studies that had late postoperative blood samples available comprised the study population. Demographic, perioperative, pathologic, and complication data were collected. Plasma samples were obtained preoperatively for all patients: on postoperative day (POD) 1 for most patients and at varying time points thereafter during the first month after surgery and beyond. Levels of VEGF were determined via enzyme-linked immunoassay (ELISA) and compared using Wilcoxon's matched pairs test. Because the numbers of specimens beyond POD 5 were limited, samples from 7-day time blocks were bundled and averaged to permit statistical analysis. RESULTS: A total of 49 patients with cancer and 30 patients with benign indications, all of whom underwent minimally invasive colorectal resection, were assessed separately. With regard to the patients with cancer, the median preoperative plasma value was 150 pg/ml, and the peak postoperative median value for the POD 14 to 20 time block was 611.1 pg/ml. Furthermore, compared with the preoperative results, significant VEGF elevations were noted on POD 3 as well as during week 2 (POD 7-13), week 3 (POD 14-20), and week 4 (POD 21-27) (p < 0.05 for each). With regard to the benign patients, the median preoperative VEGF level was 112 pg/ml, and the peak postoperative value, 286 pg/ml, was noted during postoperative week 2. Significant elevations were noted on POD 3, and for weeks 2 and 3 as well as for POD 28 and later. Between 63% and 89% of the patients at each time point beyond POD 5 had elevated VEGF levels. CONCLUSION: This preliminary study demonstrates that after minimally invasive colorectal resection for cancer, median VEGF levels are significantly elevated on POD 3 and remain increased for as long as 4 weeks. Significant elevations in a similar pattern also were noted for the benign patients. However, the baseline and postoperative median values were lower. The clinical impact from increased blood levels of VEGF is uncertain. It is possible that the growth of residual tumor deposits may be stimulated early after surgery. These results warrant a larger study as well as endothelial cell in vitro assays to determine whether postoperative plasma stimulates proliferation and invasion.
机译：背景：结直肠切除术后早期，血浆血管内皮生长因子（VEGF）升高。这种增加的持续时间未知。因为VEGF是血管生成的有效促进剂，这对肿瘤的生长至关重要，所以手术后血液VEGF水平的持续升高可能会刺激术后早期残留转移的生长。这项初步研究旨在确定结直肠切除术后第一个月的VEGF水平。方法：来自三项前瞻性研究的患者具有较晚的术后血样，包括研究人群。收集人口统计学，围手术期，病理学和并发症数据。术前采集所有患者的血浆样品：大多数患者在术后第1天（POD），之后在手术后的第一个月及以后的不同时间点采集血浆样品。通过酶联免疫测定（ELISA）确定VEGF的水平，并使用Wilcoxon配对配对测试进行比较。由于超出POD 5的样本数量有限，因此将7天时间范围内的样本打包并取平均值以进行统计分析。结果：总共评估了49例癌症患者和30例良性适应症患者，他们均接受了微创结直肠癌切除术。对于癌症患者，术前血浆中位数为150 pg / ml，POD 14至20次阻断的术后峰值中值为611.1 pg / ml。此外，与术前结果相比，在POD 3以及第2周（POD 7-13），第3周（POD 14-20）和第4周（POD 21-27）期间，发现VEGF显着升高（p <每个0.05）。对于良性患者，术前第2周的术前中位VEGF水平为112 pg / ml，术后峰值为286 pg /ml。POD3以及第2和第3周出现明显升高。以及POD 28及更高版本。在超出POD 5的每个时间点，有63％至89％的患者的VEGF水平升高。结论：这项初步研究表明，在对癌症进行微创结直肠切除术后，POD 3上的中位VEGF水平显着升高，并持续长达4周。对于良性患者，也注意到以相似的方式明显升高。但是，基线和术后中位数较低。 VEGF血药浓度升高对临床的影响尚不确定。手术后早期可能会刺激残余肿瘤沉积物的生长。这些结果需要进行更大的研究以及体外内皮细胞试验，以确定术后血浆是否刺激增殖和侵袭。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号