• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Surgical Endoscopy >Transanal endoscopic microsurgery for 135 patients with small nonadvanced low rectal cancer (iT1-iT2, iN0): short- and long-term results.
【24h】

Transanal endoscopic microsurgery for 135 patients with small nonadvanced low rectal cancer (iT1-iT2, iN0): short- and long-term results.

机译：经肛门内镜显微手术治疗135例小型非晚期低位直肠癌（iT1-iT2，iN0）：短期和长期结果。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

BACKGROUND: Local excision of rectal cancer as an alternative to radical resection for patients with small nonadvanced low rectal cancer (SNALRC) (iT1-iT2, iN0) is debated. This study aimed to analyze the short- and long-term results for a series of 135 patients with SNALRC who underwent local excision by transanal endoscopic microsurgery (TEM). METHODS: According to the study protocol, 135 patients classified by endorectal ultrasound, magnetic resonance imaging (MRI), and computed tomography (CT) imaging as having iT1 iN0 iM0 (n = 51) or iT2 iN0 iM0 (n = 84) low rectal cancer were enrolled in the study. All the patients with iT2 rectal cancer underwent neoadjuvant therapy. The definitive histologic findings showed 24 pT0 patients (17.8%), 66 pT1 patients (48.8%), and 45 pT2 patients (33.4%). RESULTS: Minor complications were observed in 12 patients (8.8%) and major complications in 2 patients (1.5%). During a median follow-up period of 97 months (range, 55-139 months), local recurrences occurred for four patients and distant metastases for two patients. The patients who experienced a recurrence had been preoperatively staged as iT2 and were low or nonresponders to neoadjuvant treatment (ypT2). At the end of the follow-up period, the disease-free survival rates were 100% for the iT1 patients and 93% for the iT2 patients CONCLUSIONS: The long-term results for adequate local excision by TEM with or without neoadjuvant radiochemotherapy in the treatment of SNALRC based on the current study protocol are not inferior to those reported in the literature for radical surgery with total mesorectal excision (TME).
机译：背景：直肠癌的局部切除术可替代小型非晚期低位直肠癌（SNALRC）（iT1-iT2，iN0）患者的根治性切除术。本研究旨在分析经肛门内镜显微手术（TEM）进行局部切除的135例SNALRC患者的短期和长期结果。方法：根据研究方案，对135例经直肠内超声，磁共振成像（MRI）和计算机断层扫描（CT）成像分类为iT1 iN0 iM0（n = 51）或iT2 iN0 iM0（n = 84）低位直肠癌的患者癌症被纳入研究。所有患有iT2直肠癌的患者都接受了新辅助治疗。明确的组织学结果显示24例pT0患者（17.8％），66例pT1患者（48.8％）和45例pT2患者（33.4％）。结果：观察到轻微并发症12例（8.8％），重大并发症2例（1.5％）。在中位随访期97个月（范围55-139个月）中，4例患者发生局部复发，2例患者发生远处转移。经历复发的患者在术前被分期为iT2，对新辅助治疗（ypT2）的反应低或无反应。在随访期结束时，iT1患者的无病生存率分别为100％和iT2患者的93％。结论：长期观察结果表明，在有或没有新辅助放化疗的情况下，TEM足以进行局部切除。根据目前的研究方案对SNALRC的治疗并不逊于文献报道的全直肠系膜切除术（TME）的根治性手术。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号