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首页> 外文期刊>Surgical Endoscopy >Hematogenous tumor cell dissemination during colonoscopy for colorectal cancer.
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Hematogenous tumor cell dissemination during colonoscopy for colorectal cancer.

机译：大肠癌结肠镜检查中的血源性肿瘤细胞扩散。

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BACKGROUND: It has long been suspected that mechanical influences may enhance the release of viable colorectal cancer cells into the circulation. The objective of this study was to determine the extent of hematogenous tumor cell spread in colorectal cancer patients during colonoscopy. METHODS: Peripheral venous blood samples were taken before and after colonoscopy from 44 patients with colorectal cancer. Blood samples were examined using a reverse-transcriptase polymerase chain reaction assay to amplify cytokeratin 20 transcripts. RESULTS: Eleven patients with colorectal cancer displayed circulating tumor cells before and after colonoscopy (25%), whereas tumor cells were detected in six of 44 patients (14%) only after the procedure (p = 0.03, McNemar's test: tumor cell detection before after colonoscopy). All control samples consistently tested negative. CONCLUSIONS: Mechanical forces may result in enhanced release of viable colorectal cancer cells into the circulation; however, the clinical significance of these results needs to be clarified.
机译：背景：人们长期以来一直怀疑机械影响可能会增强存活的结直肠癌细胞向循环系统的释放。这项研究的目的是确定结肠镜检查期间大肠癌患者中血源性肿瘤细胞扩散的程度。方法：从44例结肠直肠癌患者的结肠镜检查前后采集外周静脉血。使用逆转录酶聚合酶链反应测定法检查血液样本以扩增细胞角蛋白20转录物。结果：11例大肠癌患者在结肠镜检查前后均显示循环中的肿瘤细胞（25％），而只有44例患者中的6例（14％）在手术后才检测到肿瘤细胞（p = 0.03，McNemar's test：结肠镜检查后）。所有对照样品始终测试阴性。结论：机械力可能导致存活的结直肠癌细胞向循环中的释放增加;但是，这些结果的临床意义需要澄清。

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