Role of surgery in familial adenomatous polyposis and hereditary nonpolyposis colorectal cancer (Lynch syndrome).

Smith KD; Rodriguez Bigas MA

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Role of surgery in familial adenomatous polyposis and hereditary nonpolyposis colorectal cancer (Lynch syndrome).

机译：手术在家族性腺瘤性息肉病和遗传性非息肉病性大肠癌（林奇综合征）中的作用。

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Surgery remains the mainstay of treatment for patients who develop colorectal cancer (CRC) in the setting of a hereditary CRC syndrome. In patients with a hereditary CRC syndrome, surgery can be prophylactic, therapeutic with curative intent, and, in some cases, palliative. The type and extent of surgical resection in familial adenomatous polyposis (FAP) and in the Lynch syndrome is influenced by differences in the natural history of carcinogenesis between the two syndromes and by the effectiveness of and patient compliance with available surveillance strategies. In this article, the surgical options for the management of patients with FAP and Lynch syndrome are discussed.

机译：在遗传性CRC综合征的情况下，手术仍然是发展结直肠癌（CRC）患者的主要治疗手段。在患有遗传性CRC综合征的患者中，手术可以是预防性的，有治愈目的的治疗性手术，在某些情况下还可以是姑息性手术。家族性腺瘤性息肉病（FAP）和Lynch综合征的手术切除类型和范围受两种综合征之间自然致癌史的差异以及患者对有效监测策略的有效性和依从性的影响。在本文中，讨论了治疗FAP和Lynch综合征患者的手术选择。

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《Surgical oncology clinics of North America》 |2009年第4期|共11页
作者
Smith KD; Rodriguez Bigas MA;
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正文语种 eng
中图分类肿瘤学;
关键词
Surgical aspects; Colorectal Neoplasms; Hereditary Nonpolyposis; Syndrome; Adenomatous Polyposis Coli; Colorectal Cancer;

机译：手术方面;结直肠肿瘤;遗传性非息肉病;综合症;腺瘤性息肉病大肠菌;大肠癌;

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1. Role of surgery in familial adenomatous polyposis and hereditary nonpolyposis colorectal cancer (Lynch syndrome). [J] . Smith KD, Rodriguez Bigas MA Surgical oncology clinics of North America . 2009,第4期

机译：手术在家族性腺瘤性息肉病和遗传性非息肉病性大肠癌（林奇综合征）中的作用。
2. Difference in the Role of Loss of Heterozygosity at 10p15 (KLF6 Locus) in Colorectal Carcinogenesis between Sporadic and Familial Adenomatous Polyposis and Hereditary Nonpolyposis Colorectal Cancer Patients [J] . Michiko Miyakia, Tatsuro Yamaguchiab, Takeru lijimaa, Oncology: International Journal of Cancer Research and Treatment . 2007,第1a2期

机译：散发性和家族性腺瘤性息肉病与遗传性非息肉病大肠癌患者在10p15杂合性丧失（KLF6位点）在大肠癌发生中的作用差异
3. Hereditary colorectal cancer syndromes: familial adenomatous polyposis and lynch syndrome. [J] . Al-Sukhni W, Aronson M, Gallinger S The Surgical clinics of North America . 2008,第4期

机译：遗传性大肠癌综合征：家族性腺瘤性息肉病和私刑综合征。
4. Endoscopic guidelines for hereditary non-polyposis colorectal cancer, familial adenomatous polyposis, inflammatory bowel disease and sporadic colorectal cancer [C] . D. T. RUBIN, J. T. HETZE Falk Symposium . 2007

机译：遗传性非息肉病结直肠癌，家族性腺瘤性息肉，炎性肠病和散发性结直肠癌的内窥镜指南
5. Evaluation of the accuracy of quantitative models in predicting Lynch syndrome (hereditary nonpolyposis colorectal cancer with defective DNA mismatch repair) mutations in a population-based sample of early-onset colorectal cancer patients [D] . Carpiniello, Lauren 2007

机译：在以人群为基础的早发性大肠癌患者样本中预测定量模型预测Lynch综合征（遗传性非息肉病性大肠直肠癌，DNA失配修复缺陷）的准确性
6. Guidance on gastrointestinal surveillance for hereditary non-polyposis colorectal cancer familial adenomatous polypolis juvenile polyposis and Peutz-Jeghers syndrome [O] . M Dunlop 2002

机译：遗传性非息肉性结直肠癌家族性腺瘤性息肉青少年息肉和Peutz-Jeghers综合征胃肠道监测指南
7. Hereditary colorectal cancer : assessment of genotype-phenotype correlations and analysis of rare susceptibility genes in familial adenomatous polyposis (FAP) and hereditary nonpolyposis colorectal cancer (HNPCC) [O] . Necker Judith 2008

机译：遗传性结直肠癌：家族性腺瘤性息肉病（Fap）和遗传性非息肉病性结直肠癌（HNpCC）中罕见易感基因的基因型 - 表型相关性评估

Role of surgery in familial adenomatous polyposis and hereditary nonpolyposis colorectal cancer (Lynch syndrome).

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