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Advances in the Molecular Analysis of Soft Tissue Tumors and Clinical Implications

机译:软组织肿瘤的分子分析及其临床意义的研究进展

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The emergence of high-throughput molecular technologies has accelerated the discovery of novel diagnostic, prognostic and predictive molecular markers. Clinical implementation of these technologies is expected to transform the practice of surgical pathology. In soft tissue tumor pathology, accurate interpretation of comprehensive genomic data provides useful diagnostic and prognostic information, and informs therapeutic decisions. This article reviews recently developed molecular technologies, focusing on their application to the study of soft tissue tumors. Emphasis is made on practical issues relevant to the surgical pathologist. The concept of genomi-cally-informed therapies is presented as an essential motivation to identify targetable molecular alterations in sarcoma.
机译:高通量分子技术的出现加速了新型诊断,预后和预测性分子标志物的发现。这些技术的临床实施有望改变外科病理学的实践。在软组织肿瘤病理学中,对综合基因组数据的准确解释可提供有用的诊断和预后信息,并为治疗决策提供依据。本文回顾了最近开发的分子技术,重点介绍了它们在软组织肿瘤研究中的应用。重点放在与手术病理学家有关的实际问题上。基因组信息疗法的概念被提出来作为识别肉瘤中可靶向分子改变的基本动机。

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