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首页> 外文期刊>Supportive care in cancer: official journal of the Multinational Association of Supportive Care in Cancer >The use of low-energy laser (LEL) for the prevention of chemotherapy- and/or radiotherapy-induced oral mucositis in cancer patients: results from two prospective studies.
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The use of low-energy laser (LEL) for the prevention of chemotherapy- and/or radiotherapy-induced oral mucositis in cancer patients: results from two prospective studies.

机译：使用低能激光（LEL）预防癌症患者化疗和/或放疗引起的口腔粘膜炎：两项前瞻性研究的结果。

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BACKGROUND: Low-energy laser (LEL) treatment has been suggested as an effective and safe method to prevent and/or treat oral mucositis induced by chemotherapy and/or radiotherapy; however, it has not gained wide acceptance so far. MATERIALS AND METHODS: We conducted two clinical trials testing the LEL technique: firstly, as a secondary prevention in patients with various solid tumors treated with chemotherapy who all developed severe mucositis after a previous identical chemotherapy and, secondly, as therapeutic intervention (compared to sham illumination in a randomized way) in patients with hematological tumors receiving intensive chemotherapy and having developed low-grade oral mucositis. RESULTS: We entered 26 eligible patients in the first study and 36 were randomized in the second study. The success rate was 81% (95%CI = 61-93%) when LEL was given as a preventive treatment. In the second study, in patients with existing lesions, the therapeutic success rate was 83% (95%CI = 59-96%), which was significantly different from the success rate reached in the sham-treated patients (11%; 95%CI = 1-35%); the time to development of grade 3 mucositis was also significantly shorter in the sham-treated patients (p < 0.001). CONCLUSION: Our results strongly support the already available literature, suggesting that LEL is an effective and safe approach to prevent or treat oral mucositis resulting from cancer chemotherapy.
机译：背景：低能量激光治疗被认为是预防和/或治疗由化学疗法和/或放射疗法引起的口腔粘膜炎的有效和安全的方法。但是，到目前为止，尚未得到广泛的接受。材料与方法：我们进行了两项临床试验，测试了LEL技术：首先，作为在接受过相同化疗后均发展为严重粘膜炎的各种实体瘤患者的二级预防，其次是作为治疗性干预（与假手术相比）接受强化化疗并已发展为低度口腔黏膜炎的血液肿瘤患者。结果：我们在第一项研究中纳入了26名合格患者，在第二项研究中将36名随机分组。给予LEL预防性治疗时，成功率为81％（95％CI = 61-93％）。在第二项研究中，在存在病变的患者中，治疗成功率为83％（95％CI = 59-96％），与假治疗患者的成功率显着不同（11％; 95％ CI = 1-35％）;在接受假手术的患者中，发展为3级粘膜炎的时间也显着缩短（p <0.001）。结论：我们的结果强有力地支持了已有文献，这表明LEL是预防或治疗癌症化学疗法引起的口腔粘膜炎的一种有效且安全的方法。

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