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T-cell lymphomas Updates in Biology and Diagnosis

机译:T细胞淋巴瘤生物学和诊断方面的最新进展

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摘要

Nodal-based peripheral T-cell lymphomas are heterogeneous malignancies with overlapping morphology and clinical features. However, the current World Health Organization classification scheme separates these tumors into prognostically relevant categories. Since its publication, efforts to uncover the gene expression profiles and molecular alterations have subdivided these categories further, and distinct subgroups are emerging with specific profiles that reflect the cell of origin for these tumors and their microenvi-ronment. Identification of the perturbed biologic pathways may prove useful in selecting patients for specific therapies and associating biomarkers with survival and relapse.
机译:基于淋巴结的外周T细胞淋巴瘤是异质性恶性肿瘤,具有重叠的形态和临床特征。然而,当前的世界卫生组织分类方案将这些肿瘤分成与预后相关的类别。自从发表以来,为揭示基因表达图谱和分子变化所做的努力进一步细分了这些类别,并且出现了具有特定图谱的不同亚组,这些图谱反映了这些肿瘤及其微环境的起源细胞。扰动的生物途径的鉴定可能在选择患者进行特定疗法以及将生物标志物与生存和复发相关联方面很有用。

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