• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Sleep medicine >Advanced sleep schedules affect circadian gene expression in young adults with delayed sleep schedules
【24h】

Advanced sleep schedules affect circadian gene expression in young adults with delayed sleep schedules

机译：先进的睡眠时间表会影响延迟睡眠时间表的年轻人的昼夜节律基因表达

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background: Human circadian rhythms are regulated by the interplay between circadian genes and environmental stimuli. The influence of altered sleep-wake schedules or light on human circadian gene expression patterns is not well characterized. Methods: Twenty-one young adults were asked to keep to their usual sleep schedules and two blood samples were drawn at the end of the first week from each subject based on estimated time of dim light melatonin onset (DLMO); the first sample was obtained one and a half hours before the estimated DLMO and the second three hours later, at one and a half hours after the estimated DLMO. During the second week, participants were randomized into two groups, one that received a one hour blue-light (λmax=470nm) exposure in the morning and one that received a comparable morning dim-light exposure. Two blood samples were obtained at the same clock times as the previous week at the end of the second week. Results: We measured the expression of 10 circadian genes in response to sleep-wake schedule advancement and morning blue-light stimulation in the peripheral blood of 21 participants during a two-week field study. We found that nine of the 10 circadian genes showed significant expression changes from the first to the second week for participants in both the blue-light and dim-light groups, likely reflecting significant advances in circadian phase. Conclusions: This wholesale change in circadian gene expression may reflect considerable advances in circadian phase (i.e., advance in DLMO) from the first to the second week resulting from the advanced, daily personal light exposures.
机译：背景：人类昼夜节律受昼夜节律基因与环境刺激之间的相互作用所调节。睡眠-睡眠时间表或光线改变对人类昼夜节律基因表达模式的影响尚不十分清楚。方法：要求二十一名年轻成年人保持其正常的睡眠计划，并在第一周结束时根据估计的暗淡褪黑激素发作时间（DLMO）从每名受试者中抽取两份血液样本。第一个样本是在估计的DLMO前一个半小时获得的，第二个样本是在估计的DLMO之后一个半小时后获得的。在第二周，参与者被随机分为两组，一组在早晨接受一小时的蓝光（λmax= 470nm）照射，另一组接受类似的早晨暗光照射。在第二周结束时，在与前一周相同的时钟时间获得了两个血液样本。结果：在为期两周的实地研究中，我们测量了21位参与者外周血中10种昼夜节律基因的表达，以响应睡眠-觉醒时间表的进展和早晨蓝光的刺激。我们发现10个昼夜节律基因中的9个在蓝光和暗光组的参与者从第一周到第二周都显示出明显的表达变化，这很可能反映了昼夜节律阶段的显着进展。结论：昼夜节律基因表达的这种全面变化可能反映了昼夜节律阶段从第一周到第二周的相当大的进步（即DLMO的进步），这是由于每天的日常个人光照增加所致。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号