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首页> 外文期刊>Pain. >Analgesic effect of subarachnoid neostigmine in two patients with cancer pain.
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Analgesic effect of subarachnoid neostigmine in two patients with cancer pain.

机译：蛛网膜下腔新斯的明的镇痛作用在两名癌痛患者中。

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Two patients suffering with severe pain due to metastatic abdominal neoplasm were selected to examine whether subarachnoid neostigmine provided effective pain relief. Neostigmine was injected through a catheter introduced into the subarachnoid space at L4-L5. Patients were monitored for changes in arterial blood pressure, cardiac and respiratory rates, body temperature, level of consciousness and neurologic change. Pain was classified by the patients on a verbal four-grade scale, and analgesia was classified on a verbal three-grade scale. Complete pain relief was obtained 2 h after neostigmine (0.2 mg) in one patient and 4 h after neostigmine (0.1 mg) in the second patient. Pain of mild intensity returned 20 and 22 h after drug administration, respectively. Gastrointestinal discomfort was observed in both cases, but nausea and vomiting occurred only in the patient treated with the highest dose of neostigmine. No significant change in the monitored parameters was observed, except for a 6-h period of decreased blood pressure in the patient treated with the lower dose of neostigmine which required no specific treatment. The results obtained in these anecdotal cases indicate that subarachnoid neostigmine may provide analgesia in patients with pain arising from neoplasia, but further studies using controlled trials are needed before the drug is brought into clinical use.
机译：选择两名因转移性腹部肿瘤而遭受严重疼痛的患者，检查蛛网膜下腔新斯的明是否能有效缓解疼痛。通过在L4-L5的蛛网膜下腔引入导管注射新斯的明。监测患者的动脉血压，心脏和呼吸频率，体温，意识水平和神经系统变化。疼痛根据患者的语言等级分为四级，而镇痛则根据患者的语言等级分为三级。一名患者在新斯的明（0.2 mg）后2 h和另一名患者在新斯的明（0.1 mg）后4 h获得了完全的疼痛缓解。给药后20小时和22小时分别出现轻度疼痛。在这两种情况下均观察到胃肠道不适，但仅在使用最高剂量的新斯的明治疗的患者中出现恶心和呕吐。除了用低剂量新斯的明治疗的患者不需要任何特殊治疗，血压降低了6小时后，观察到的参数没有观察到显着变化。在这些轶事病例中获得的结果表明，蛛网膜下腔新斯的明可以为因肿瘤形成而引起的疼痛的患者提供镇痛作用，但在将该药物投入临床使用之前，需要使用对照试验进行进一步的研究。

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