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首页> 外文期刊>Parasitology >Extending from PARs in Caenorhabditis elegans to homologues in Haemonchus contortus and other parasitic nematodes.
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Extending from PARs in Caenorhabditis elegans to homologues in Haemonchus contortus and other parasitic nematodes.

机译：从秀丽隐杆线虫的PAR延伸到扭曲的Haemonchus contortus和其他寄生线虫中的同系物。

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Signal transduction molecules play key roles in the regulation of developmental processes, such as morphogenesis, organogenesis and cell differentiation in all organisms. They are organized into 'pathways' that represent a coordinated network of cell-surface receptors and intracellular molecules, being involved in sensing environmental stimuli and transducing signals to regulate or modulate cellular processes, such as gene expression and cytoskeletal dynamics. A particularly important group of molecules implicated in the regulation of the cytoskeleton for the establishment and maintenance of cell polarity is the PAR proteins (derived from partition defective in asymmetric cell division). The present article reviews salient aspects of PAR proteins involved in the early embryonic development and morphogenesis of the free-living nematode Caenorhabditis elegans and some other organisms, with an emphasis on the molecule PAR-1. Recent advances in the knowledge and understanding of PAR-1 homologues from the economically important parasitic nematode, Haemonchus contortus, of small ruminants is summarized and discussed in the context of exploring avenues for future research in this area for parasitic nematodes.
机译：信号转导分子在所有生物的发育过程（例如形态发生，器官发生和细胞分化）的调节中起关键作用。它们被组织成“通路”，代表细胞表面受体和细胞内分子的协调网络，参与感知环境刺激并转导信号以调节或调节细胞过程，例如基因表达和细胞骨架动力学。 PAR蛋白（源自不对称细胞分裂中的分区缺陷）与细胞骨架的调节有关，以建立和维持细胞极性特别重要。本文概述了与自由生存的线虫秀丽隐杆线虫和一些其他生物的早期胚胎发育和形态发生有关的PAR蛋白的重要方面，重点是分子PAR-1。在经济上重要的小反刍动物寄生线虫Haemonchus contortus的PAR-1同源物的知识和理解上的最新进展，在探索该寄生虫线虫的未来研究途径的背景下进行了总结和讨论。

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