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首页> 外文期刊>Parasitology >In vivo response of Mesocestoides vogae to human insulin.
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In vivo response of Mesocestoides vogae to human insulin.

机译:Mesocestoides vogae对人胰岛素的体内反应。

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SUMMARY: Successful host invasion by parasitic helminths involves detection and appropriate response to a range of host-derived signals. Insulin signal response pathways are ancient and highly-conserved throughout the metazoans. However, very little is known about helminth insulin signalling and the potential role it may play in host-parasite interactions. The response of Mesocestoides vogae (Cestoda: Cyclophyllidea) larvae to human insulin was investigated, focusing on tyrosine-phosphorylation status, glucose content, survival and asexual reproduction rate. Parasite larvae were challenged with different levels of insulin for variable periods. The parameters tested were influenced by human insulin, and suggested a host-parasite molecular dialogue.
机译:摘要:寄生性蠕虫成功入侵宿主涉及检测和对一系列宿主衍生信号的适当响应。胰岛素信号反应途径是古老的,在后生动物中高度保守。然而,关于蠕虫胰岛素信号及其在宿主-寄生虫相互作用中可能发挥的潜在作用知之甚少。研究了菜豆中肠蝇(Mesocestoides vogae)(Cestoda:Cyclophyllidea)幼虫对人胰岛素的反应,重点是酪氨酸磷酸化状态,葡萄糖含量,存活率和无性繁殖率。寄生虫的幼虫在不同的时期受到不同水平的胰岛素的攻击。测试的参数受人胰岛素的影响,并提出了宿主-寄生虫分子对话。

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