• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Parasitology >The animal trypanosomiases and their chemotherapy: a review
【24h】

The animal trypanosomiases and their chemotherapy: a review

机译：动物锥虫酶及其化学疗法：一个综述

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Pathogenic animal trypanosomes affecting livestock have represented a major constraint to agricultural development in Africa for centuries, and their negative economic impact is increasing in South America and Asia. Chemotherapy and chemoprophylaxis represent the main means of control. However, research into new trypanocides has remained inadequate for decades, leading to a situation where the few compounds available are losing efficacy due to the emergence of drug-resistant parasites. In this review, we provide a comprehensive overview of the current options available for the treatment and prophylaxis of the animal trypanosomiases, with a special focus on the problem of resistance. The key issues surrounding the main economically important animal trypanosome species and the diseases they cause are also presented. As new investment becomes available to develop improved tools to control the animal trypanosomiases, we stress that efforts should be directed towards a better understanding of the biology of the relevant parasite species and strains, to identify new drug targets and interrogate resistance mechanisms.
机译：几个世纪以来，影响牲畜的病原性动物锥虫成为非洲农业发展的主要制约因素，其负面的经济影响在南美和亚洲正在增加。化学疗法和化学预防是控制的主要手段。然而，数十年来对新的锥虫病的研究仍然不足，导致由于耐药性寄生虫的出现而使少数可用化合物失去功效的情况。在这篇综述中，我们提供了可用于治疗和预防动物锥虫病的当前选择的全面概述，特别关注了耐药性问题。还介绍了围绕主要经济上重要的动物锥虫物种及其引起的疾病的关键问题。随着有新的投资可用于开发改进的工具来控制动物锥虫病，我们强调应该努力使人们更好地了解相关寄生虫物种和菌株的生物学特性，从而确定新的药物靶标和询问耐药性机制。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号