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首页> 外文期刊>Biomaterials >Dexamethasone/PLGA microspheres for continuous delivery of an anti-inflammatory drug for implantable medical devices.
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Dexamethasone/PLGA microspheres for continuous delivery of an anti-inflammatory drug for implantable medical devices.

机译：地塞米松/ PLGA微球用于为植入式医疗设备连续输送抗炎药。

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摘要

The purpose of this research was to develop polylactic-co-glycolic acid (PLGA) microspheres for continuous delivery of dexamethasone for over a 1-month period, in an effort to suppress the acute and chronic inflammatory reactions to implants such as biosensors, which interfere with their functionality. The microspheres were prepared using an oil-in-water emulsion technique. The oil phase was composed of 9:1 dichloromethane to methanol with dissolved PLGA and dexamethasone. Some microspheres were predegraded for 1 or 2 weeks. Ten percent of polyethylene glycol was added to the oil phase in alternative formulations to delay drug release. The in vitro release studies were performed in a constant temperature (37 C) warm room, in phosphate-buffered saline at sink conditions. Drug loading and release rates were determined by HPLC-UV analysis. The standard microsphere systems did not provide the desired release profile since, following an initial burst release, a delay of 2 weeks occurred prior to continuous drug release. Predegraded microspheres started to release dexamethasone immediately but the rate of release decreased after only 2 weeks. A mixed standard and predegraded microsphere system was used to avoid this delay and to provide continuous release of dexamethasone for 1 month.
机译：这项研究的目的是开发聚乳酸-乙醇酸共聚物（PLGA）微球，用于在1个月的时间内连续输送地塞米松，以抑制对植入物（如生物传感器）的急性和慢性炎症反应，这些反应会干扰与他们的功能。使用水包油乳液技术制备微球。油相由9：1二氯甲烷与甲醇，溶解的PLGA和地塞米松组成。一些微球被预先降解了1或2周。在替代配方中将10％的聚乙二醇添加到油相中以延迟药物释放。体外释放研究是在恒温（37°C）的温暖房间中，在水槽条件下于磷酸盐缓冲液中进行的。通过HPLC-UV分析确定药物加载和释放速率。标准的微球系统无法提供所需的释放曲线，因为在最初的突释释放后，在连续释放药物之前要延迟2周。预降解的微球开始立即释放地塞米松，但仅2周后释放速率下降。使用混合标准品和预降解的微球系统来避免这种延迟，并提供地塞米松的连续释放1个月。

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