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首页> 外文期刊>Pediatric allergy, immunology, and pulmonology >As Needed Use of Inhaled Corticosteroids for Management of Mild Persistent Asthma in Children
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As Needed Use of Inhaled Corticosteroids for Management of Mild Persistent Asthma in Children

机译：根据需要使用吸入性糖皮质激素治疗儿童轻度持续性哮喘

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摘要

In a recent publication, Martinez and colleagues reported a randomized, double-blind, placebo-controlled trial to assess effectiveness of ICSs when used as needed along with the patients' regular short-acting beta2agonists in children with well-controlled mild persistent asthma.1 Children 6-18 years old with controlled asthma on low-dose ICSs were enrolled. Patients were excluded if they were admitted to the hospital for asthma exacerbation in the previous year, had an asthma exacerbation in the last 3 months or > 2 in the previous year, had a baseline forced expiratory volume in 1 second of < 60% predicted at the screening visit, or had a history of life-threatening asthma. Patients were enrolled in a 4-week run-in period, and those whose asthma remained controlled were randomly assigned to one of the 4 arms: beclomethasone (40 meg/puff, one puff twice daily) with beclomethasone plus albuterol as rescue (combined group), beclomethasone twice daily with placebo plus albuterol as rescue (daily group), placebo twice daily with beclomethasone plus albuterol as rescue (rescue group), and placebo twice daily plus placebo and albuterol as rescue (placebo group).
机译：在最近的出版物中，Martinez及其同事报告了一项随机，双盲，安慰剂对照试验，以评估在控制良好的轻度持续性哮喘患儿中，按需使用ICSs以及患者常规的短效β2受体激动剂的有效性。纳入6-18岁小剂量ICSs控制性哮喘患儿。如果患者在前一年因哮喘急性发作而入院，在最近3个月内哮喘急性发作或在过去一年≥2例，在1秒内基线强迫呼气量低于预测的60％，则排除患者进行筛查或有威胁生命的哮喘病史。入组患者为期4周，将哮喘得到控制的患者随机分配至4组中的一组：倍氯米松（40毫克/粉扑，每天两次，一次粉扑），并以倍氯米松加沙丁胺醇作为挽救药物（合并组） ），倍氯米松每天两次，以安慰剂加沙丁胺醇作为急救剂（每日一组），安慰剂每天两次，倍氯米松加沙丁胺醇作为急救剂（救援组）和安慰剂，每天两次，安慰剂和沙丁胺醇作为急救剂（安慰剂组）。

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