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首页> 外文期刊>Pediatric neurology >Multiple sclerosis vs acute disseminated encephalomyelitis in childhood.
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Multiple sclerosis vs acute disseminated encephalomyelitis in childhood.

机译：儿童多发性硬化与急性弥漫性脑脊髓炎。

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摘要

The initial presenting clinical and laboratory findings of either acute disseminated encephalomyelitis or the first attack of multiple sclerosis in the pediatric population were compared and contrasted. A retrospective review of the medical records was conducted of all children younger than 17 years who presented with either the diagnosis of acute disseminated encephalomyelitis or multiple sclerosis between 1987 and 2001. Seventeen cases of clinically definite multiple sclerosis (seven female, mean age 12.4 +/- 4.5 years) and seven cases of acute disseminated encephalomyelitis (three female; mean age 8.7 +/- 3.8 years) were reviewed. Systemic and nonfocal neurologic symptoms were more commonly evident in acute disseminated encephalomyelitis than in multiple sclerosis: fever (43% vs 6%), headache (57% vs 24%), fatigue (71% vs 29%), vomiting (57% vs 0%), and encephalopathy (71% vs 6%). In multiple sclerosis patients, T(2)-weighted white matter magnetic resonance imaging lesions were more commonly locatedin the corpus callosum (64% vs 17%) and the periventricular area (91% vs 50%) compared with those in patients with acute disseminated encephalomyelitis. These results suggest that acute disseminated encephalomyelitis and multiple sclerosis can be differentiated to some degree according to clinical and radiologic data at initial presentation, which is important because the long-term prognosis for childhood multiple sclerosis appears to be less favorable.
机译：比较和对比了小儿人群急性弥漫性脑脊髓炎或多发性硬化的首次发作的初步临床和实验室发现。对1987年至2001年间诊断为急性播散性脑脊髓炎或多发性硬化症的所有17岁以下儿童进行了医疗记录的回顾性研究。17例临床上明确的多发性硬化症病例（七名女性，平均年龄12.4 + / -4.5岁）和7例急性播散性脑脊髓炎（3名女性;平均年龄8.7 +/- 3.8岁）进行了回顾。与多发性硬化症相比，系统性和非局灶性神经系统症状在多发性硬化症中更为常见：发烧（43％vs 6％），头痛（57％vs 24％），疲劳（71％vs 29％），呕吐（57％vs. 0％）和脑病（71％比6％）。在多发性硬化症患者中，与急性播散患者相比，T（2）加权白质磁共振成像病变更常见于call体（64％vs 17％）和脑室周围区域（91％vs 50％）。脑脊髓炎。这些结果表明，急性弥漫性脑脊髓炎和多发性硬化症可以在初次就诊时根据临床和影像学资料进行一定程度的区分，这很重要，因为儿童多发性硬化症的长期预后似乎较差。

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