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首页> 外文期刊>Pediatrics: Official Publication of the American Academy of Pediatrics >A randomized controlled trial of zinc as adjuvant therapy for severe pneumonia in young children
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A randomized controlled trial of zinc as adjuvant therapy for severe pneumonia in young children

机译：锌作为辅助治疗严重儿童肺炎的随机对照试验

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BACKGROUND AND OBJECTIVE: Diarrhea and pneumonia are the leading causes of illness and death in children <5 years of age. Zinc supplementation is effective for treatment of acute diarrhea and can prevent pneumonia. In this trial, we measured the efficacy of zinc when given to children hospitalized and treated with antibiotics for severe pneumonia. METHODS: We enrolled 610 children aged 2 to 35 months who presented with severe pneumonia defined by the World Health Organization as cough and/or difficult breathing combined with lower chest indrawing. All children received standard antibiotic treatment and were randomized to receive zinc (10 mg in 2- to 11-month-olds and 20 mg in older children) or placebo daily for up to 14 days. The primary outcome was time to cessation of severe pneumonia. RESULTS: Zinc recipients recovered marginally faster, but this difference was not statistically significant (hazard ratio = 1.10, 95% CI 0.94-1.30). Similarly, the risk of treatment failure was slightly but not significantly lower in those who received zinc (risk ratio = 0.88 95% CI 0.71-1.10). CONCLUSIONS: Adjunct treatment with zinc reduced the time to cessation of severe pneumonia and the risk of treatment failure only marginally, if at all, in hospitalized children.
机译：背景与目的：腹泻和肺炎是5岁以下儿童疾病和死亡的主要原因。补锌可有效治疗急性腹泻并可以预防肺炎。在该试验中，我们测量了重症肺炎住院和接受抗生素治疗的儿童服用锌的功效。方法：我们招募了610名2到35个月大的儿童，他们患有世界卫生组织定义为咳嗽和/或呼吸困难并伴有下胸部抽搐的严重肺炎。所有儿童均接受标准抗生素治疗，并随机接受锌治疗（2至11个月大的儿童10毫克，年龄较大的儿童20毫克）或安慰剂，每天最多14天。主要结局是停止严重肺炎的时间。结果：锌接受者的恢复速度略快，但差异无统计学意义（危险比= 1.10，95％CI 0.94-1.30）。同样，接受锌治疗的患者治疗失败的风险略有降低，但没有显着降低（风险比= 0.88 95％CI 0.71-1.10）。结论：锌的辅助治疗减少了住院儿童的严重肺炎停止时间，并且治疗失败的风险很小（即使有的话）。

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