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首页> 外文期刊>Pediatrics: Official Publication of the American Academy of Pediatrics >The prevalence of infections with Trichophyton tonsurans in schoolchildren: the CAPITIS study.
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The prevalence of infections with Trichophyton tonsurans in schoolchildren: the CAPITIS study.

机译：CAPITIS研究显示小学生口气单胞菌的感染率。

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BACKGROUND: Although Trichophyton tonsurans has become the leading cause of tinea capitis in the United States, reported infection rates vary widely, and prevalence estimates for the pediatric population at large remain poorly characterized. METHODS: A prospective, cross-sectional, surveillance study of children attending kindergarten through fifth grade in 44 schools across the bi-state (Kansas/Missouri), Kansas City metropolitan area was conducted. Fungal cultures were collected from all participants, and molecular analyses were used to characterize the patterns of infection within the population. RESULTS: Of 10,514 children (age: 8.3 +/- 1.9 years) examined for the presence of T tonsurans on their scalps, 6.6% exhibited positive cultures. Infection rates at participating schools ranged from 0% to 19.4%, exceeding 30% at a given grade level in some schools. Black children demonstrated the highest rates of infection (12.9%), with prevalence estimates for the youngest members of this racial group approaching 18%. Infection rates for Hispanic (1.6%) and white (1.1%) children were markedly lower. A single genetic strain of T tonsurans was identified in only 16.6% of classrooms, whereas each child harbored a unique genetic strain in 51.4%. CONCLUSIONS: We report a large-scale, citywide, surveillance study of T tonsurans infection rates among children in primary school in a metropolitan area. The striking prevalence rates and genetic heterogeneity among the fungal isolates confirm the relatively large degree to which this pathogen has become integrated into metropolitan communities.
机译：背景：尽管在美国，扁桃体毛癣菌已成为头癣的主要诱因，但据报道感染率差异很大，而对整个儿科人群的患病率估计值仍不明确。方法：对堪萨斯城州两州（堪萨斯州/密苏里州）的44所学校的幼儿园至五年级的儿童进行了前瞻性，横断面，监督性研究。从所有参与者中收集真菌培养物，并使用分子分析来表征种群内的感染模式。结果：在10,514名儿童（年龄：8.3 +/- 1.9岁）中，他们的头皮上存在T扁桃体，其中6.6％的人呈阳性培养。参与学校的感染率从0％到19.4％，在某些学校达到给定年级水平时超过30％。黑人儿童的感染率最高（12.9％），该族裔最小成员的患病率估计接近18％。西班牙裔（1.6％）和白人（1.1％）儿童的感染率明显较低。仅在教室的16.6％中发现了单一的T硫脲菌遗传菌株，而每个孩子中只有51.4％的人携带独特的遗传菌株。结论：我们报告了在大城市范围内小学范围内的儿童中对扁桃体感染率的大规模，大规模监测研究。真菌分离株之间惊人的患病率和遗传异质性证实了该病原体已在较大程度上整合到城市社区中。

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