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首页> 外文期刊>Pediatrics: Official Publication of the American Academy of Pediatrics >Omega-3 long-chain polyunsaturated fatty acids for extremely preterm infants: A systematic review
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Omega-3 long-chain polyunsaturated fatty acids for extremely preterm infants: A systematic review

机译：Omega-3长链多不饱和脂肪酸用于极早产婴儿的系统评价

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摘要

BACKGROUND AND OBJECTIVE: Omega-3 long chain polyunsaturated fatty acid (LCPUFA) exposure can be associated with reduced neonatal morbidities. We systematically review the evidence for the benefits of omega-3 LCPUFAs for reducing neonatal morbidities in extremely preterm infants. METHODS: Data sources were PubMed, Embase, Center for Reviews and Dissemination, and the Cochrane Register of Controlled Trials. Original studies were selected that included infants born at <29 weeks' gestation, those published until May 2013, and those that evaluated the relationship between omega-3 LCPUFA supplementation and major adverse neonatal outcomes. Data were extracted on study design and outcome. Effect estimates were pooled. RESULTS: Of the 1876 studies identified, 18 randomized controlled trials (RCTs) and 6 observational studies met the defined criteria. No RCT specifically targeted a population of extremely preterm infants. Based on RCTs, omega-3 LCPUFA was not associated with a decreased risk of bronchopulmonary dysplasia in infants overall (pooled risk ratio [RR] 0.97, 95% confidence interval [CI] 0.82-1.13], 12 studies, n = 2809 infants); however, when considering RCTs that include only infants born at ≤32 weeks' gestation, a trend toward a reduction in the risk of bronchopulmonary dysplasia (pooled RR 0.88, 95% CI 0.74-1.05, 7 studies, n = 1156 infants) and a reduction in the risk of necrotizing enterocolitis (pooled RR 0.50, 95% CI 0.23-1.10, 5 studies, n = 900 infants) was observed with LCPUFA. CONCLUSIONS: Large-scale interventional studies are required to determine the clinical benefits of omega-3 LCPUFA, specifically in extremely preterm infants, during the neonatal period.
机译：背景与目的：暴露于Omega-3长链多不饱和脂肪酸（LCPUFA）可以降低新生儿的发病率。我们系统地回顾了omega-3 LCPUFAs降低极早产儿新生儿发病率的益处的证据。方法：数据来源为PubMed，Embase，审查和传播中心以及对照试验的Cochrane登记册。选择的原始研究包括胎龄小于29周的婴儿，2013年5月之前公布的婴儿，以及评估补充omega-3 LCPUFA与严重新生儿不良后果之间的关系的婴儿。提取研究设计和结果的数据。汇总效果估计。结果：在确定的1876项研究中，有18项随机对照试验（RCT）和6项观察性研究均符合既定标准。没有RCT专门针对极早产婴儿的人群。根据RCT，omega-3 LCPUFA总体上与降低婴儿支气管肺发育不良的风险无关（合并风险比[RR] 0.97，95％置信区间[CI] 0.82-1.13]，12个研究，n = 2809例婴儿） ;但是，当考虑仅包括妊娠≤32周出生的婴儿的RCT时，有降低支气管肺发育不良风险的趋势（合并RR 0.88、95％CI 0.74-1.05、7个研究，n = 1156婴儿）和使用LCPUFA观察到，坏死性小肠结肠炎的风险降低（合并RR 0.50，95％CI 0.23-1.10，5个研究，n = 900例婴儿）。结论：需要进行大规模的干预研究以确定omega-3 LCPUFA在新生儿期间的临床益处，特别是在极早产儿。

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