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首页> 外文期刊>Pediatrics: Official Publication of the American Academy of Pediatrics >Incidence of childhood and adolescent melanoma in the United States: 1973-2009
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Incidence of childhood and adolescent melanoma in the United States: 1973-2009

机译：美国儿童和青少年黑色素瘤的发病率：1973-2009年

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OBJECTIVE: Childhood and adolescent melanoma is rare but has been increasing. To gain insight into possible reasons underlying this observation, we analyzed trends in melanoma incidence diagnosed between the ages of 0 and 19 years among US whites by gender, stage, age at diagnosis, and primary site. We also investigated incidence trends by UV-B exposure levels. METHODS: By using Surveillance, Epidemiology, and End Results (SEER) program data (1973-2009), we calculated age-adjusted incidence rates (IRs), annual percent changes, and 95% confidence intervals for each category of interest. Incidence trends were also evaluated by using joinpoint and local regression models. SEER registries were categorized with respect to low or high UV-B radiation exposure. RESULTS: From 1973 through 2009, 1230 children of white race were diagnosed with malignant melanoma. Overall, pediatric melanoma increased by an average of 2% per year (95% confidence interval, 1.4%-2.7%). Girls, 15- to 19-year-olds, and individuals with low UV-B exposure had significantly higher IRs than boys, younger children, and those living in SEER registries categorized as high UV-B. Over the study period, boys experienced increased IRs for melanoma on the face and trunk, and females on the lower limbs and hip. The only decreased incidence trend we observed was among 15- to 19-year-olds in the high UV-B exposure group from 1985 through 2009. Local regression curves indicated similar patterns. CONCLUSIONS: These results may help elucidate possible risk factors for adolescent melanoma, but additional individual-level studies will be necessary to determine the reasons for increasing incidence trends.
机译：目的：儿童和青少年黑色素瘤很少见，但一直在增加。为了深入了解这一观察结果的可能原因，我们按性别，分期，诊断年龄和原发部位分析了美国白人在0至19岁之间诊断出的黑色素瘤发病率趋势。我们还通过UV-B暴露水平调查了发病率趋势。方法：通过使用监测，流行病学和最终结果（SEER）程序数据（1973-2009年），我们为每种感兴趣的类别计算了年龄调整后的发生率（IR），年变化率和95％置信区间。还通过使用连接点和局部回归模型评估了发病趋势。 SEER注册管理机构针对低或高UV-B辐射暴露进行了分类。结果：从1973年到2009年，有1230名白人儿童被诊断出患有恶性黑色素瘤。总体而言，小儿黑色素瘤平均每年增加2％（95％的置信区间为1.4％-2.7％）。 15至19岁的女孩和UV-B暴露量低的人的IR明显高于男孩，年幼的孩子以及居住在SEER注册表中的UV-B者。在研究期间，男孩面部和躯干黑色素瘤的IR升高，女性下肢和臀部的IR升高。我们观察到的唯一下降的趋势是从1985年至2009年在高UV-B暴露组中的15至19岁人群中。局部回归曲线显示出相似的模式。结论：这些结果可能有助于阐明青春期黑色素瘤的可能危险因素，但是有必要进行额外的个体水平研究以确定发病率增加的原因。

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