Toxicokinetic studies reveal variability in earthworm pollutant handling

Spurgeon D.J.; Lister L.; Kille P.; Pereira M.G.; Wright J.; Svendsen C.

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Toxicokinetic studies reveal variability in earthworm pollutant handling

机译：毒代动力学研究揭示了pollutant污染物处理的可变性

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A frequent characteristic of earthworms collected from contaminated sites is that they show considerable variation in measured tissue chemical concentrations. What is not certain is whether this variation results from local scale heterogeneity in soil concentrations and associated variation in exposure or rather from systematic and biologically based differences in earthworm pollutant handling. To assess patterns of earthworm chemical uptake and associated variation, accumulation was investigated in two bespoke toxicokinetic studies with the organic chemicals chlorpyrifos and fluoranthene and in a reanalysis of two published toxicokinetic studies with the metals Pb and Cd. The analysis of all data-sets highlighted extensive variation around one compartment model fits. Such consistently high variability, despite the homogenous nature of exposure within the test systems, hints at extensive biological variation in earthworms within the pathways involved in pollutant handling (uptake, metabolism, excretion) which goes beyond the simple methodological variation of a single test. The identified variation between individuals has important implications in areas such as biomarker analyses and secondary poisoning assessment. Further it indicates the presence of substantive selectable variation in pollutant handling that could support the development of pollutant tolerance in earthworms.

机译：从受污染的地方收集的of的一个常见特征是，它们在测得的组织化学浓度中显示出很大的差异。尚不确定的是，这种变化是由于土壤浓度的局部尺度异质性和相关的暴露变化，还是由于pollutant污染物处理的系统性和生物学性差异造成的。为了评估worm化学吸收的模式及其相关变化，在两项使用有机毒死rif和荧蒽的定制毒代动力学研究中，以及在对两项已发表的用金属铅和镉进行毒代动力学研究的重新分析中，研究了accumulation的积累。对所有数据集的分析突出显示了围绕一个隔室模型拟合的广泛变化。尽管测试系统中的暴露具有同质性，但这种始终如一的高可变性暗示了pollutant在污染物处理（吸收，代谢，排泄）所涉及的途径内的广泛生物学变化，这超出了单个测试的简单方法学变化。在个体之间确定的变异对生物标志物分析和二次中毒评估等领域具有重要意义。此外，它表明污染物处理中存在实质性的选择性变化，这可能支持support对污染物的耐受性的发展。

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《Pedobiologia》 |2011年第s1期|共6页
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Spurgeon D.J.; Lister L.; Kille P.; Pereira M.G.; Wright J.; Svendsen C.;
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正文语种 eng
中图分类土壤生物学;
关键词
Biomarkers; Body burden; Ecotoxicology; Food chain transfer; Tolerance; Toxicokinetics;

机译：生物标志物;身体负担;生态毒理学;食物链转移;耐受性;毒代动力学;

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2. Sensitivity of Different Cytotoxic Responses of Vero Cells Exposed to Organic Chemical Pollutants and their Reliability in the Bio-toxicity Test of Trace Chemical Pollutants [J] . TING-TING LIAO, YAN-LING SHI, JIAN-WEI JIA, 生物医学与环境科学（英文版） . 2010,第003期
3. Toxicokinetic studies reveal variability in earthworm pollutant handling [J] . Spurgeon D.J., Lister L., Kille P., Pedobiologia . 2011,第S1期

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Toxicokinetic studies reveal variability in earthworm pollutant handling

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