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首页> 外文期刊>Pediatrics: Official Publication of the American Academy of Pediatrics >In utero exposure to dichlorodiphenyltrichloroethane (DDT) and dichlorodiphenyldichloroethylene (DDE) and neurodevelopment among young Mexican American children.
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In utero exposure to dichlorodiphenyltrichloroethane (DDT) and dichlorodiphenyldichloroethylene (DDE) and neurodevelopment among young Mexican American children.

机译：在宫内暴露于二氯二苯基三氯乙烷（DDT）和二氯二苯基二氯乙烯（DDE）以及墨西哥裔美国年幼儿童的神经发育。

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OBJECTIVE: We investigated the relationship between prenatal exposure to dichlorodiphenyltrichloroethane (DDT) and dichlorodiphenyldichloroethylene (DDE) and neurodevelopment of Mexican farm-workers' children in California. METHODS: Participants from the Center for the Health Assessment of Mothers and Children of Salinas study, a birth cohort study, included 360 singletons with maternal serum measures of p,p'-DDT, o,p'-DDT, and p,p'-DDE. Psychomotor development and mental development were assessed with the Bayley Scales of Infant Development at 6, 12, and 24 months. RESULTS: We found a approximately 2-point decrease in Psychomotor Developmental Index scores with each 10-fold increase in p,p'-DDT levels at 6 and 12 months (but not 24 months) and p,p'-DDE levels at 6 months only. We found no association with mental development at 6 months but a 2- to 3-point decrease in Mental Developmental Index scores for p,p'-DDT and o,p'-DDT at 12 and 24 months, corresponding to 7- to 10-point decreases across the exposure range. Even when mothers had substantial exposure, breastfeeding was usually associated positively with Bayley scale scores. CONCLUSIONS: Prenatal exposure to DDT, and to a lesser extent DDE, was associated with neurodevelopmental delays during early childhood, although breastfeeding was found to be beneficial even among women with high levels of exposure. Countries considering the use of DDT should weigh its benefit in eradicating malaria against the negative associations found in this first report on DDT and human neurodevelopment.
机译：目的：我们调查了产前暴露于二氯二苯基三氯乙烷（DDT）和二氯二苯基二氯乙烯（DDE）与加利福尼亚州墨西哥农场工人子女的神经发育之间的关系。方法：一项来自出生队列研究的盐沼母亲和儿童健康评估中心的研究对象包括360个单身人士，其孕妇血清中的p，p'-DDT，o，p'-DDT和p，p' -DDE。用贝利婴儿发育量表在6、12和24个月评估精神运动发育和智力发育。结果：我们发现精神运动发育指数得分降低了约2点，在6和12个月（而非24个月）时p，p'-DDT水平每升高10倍，在6个月时p，p'-DDE水平每升高10倍仅几个月。我们发现在6个月时与智力发育无关，但在12和24个月时p，p'-DDT和o，p'-DDT的心理发育指数得分降低了2到3点，相当于7到10点在整个曝光范围内降低。即使母亲有大量暴露，母乳喂养通常也与贝利量表得分呈正相关。结论：尽管发现母乳喂养即使对暴露水平较高的妇女也是有益的，但产前暴露于DDT以及DDE的程度较小与儿童早期的神经发育延迟有关。正在考虑使用滴滴涕的国家应对照第一份关于滴滴涕和人类神经发育的报告中的消极关联，权衡其在消灭疟疾方面的益处。

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