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首页> 外文期刊>Pediatric dentistry >Oral manifestations of hyperparathyroidism secondary to familial hypophosphatemic rickets.
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Oral manifestations of hyperparathyroidism secondary to familial hypophosphatemic rickets.

机译：继发于家族性低磷酸盐血症性ets病的甲状旁腺功能亢进症的口腔表现。

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A 14-year-old male with familial hypophosphatemic rickets, being treated with oral phosphate and calcitriol therapy, presented to the Division of Pediatric Dentistry, Children's Hospital of Pittsburgh of the University of Pittsburgh Medical Center, Pittsburgh, Pa. A panoramic radiograph showed multifocal, multilocular lesions in the mandible leading to surgical exploration and biopsy. Histopathological evaluation of the largest lesion showed features consistent with central giant cell granuloma. Given the patient's history, hyperparathyroidism was suspected. Laboratory data showed an elevated parathyroid hormone of 152 pg/ml (normal range equals nine to 69). This confirmed the diagnosis of multiple brown tumors in the mandible associated with secondary hyperparathyroidism, which was attributed to high-dose phosphate treatment. After endocrinology consultation, calcitriol therapy was increased. Improvement of the patient's brown tumors is expected with medical therapy. The purpose of this case report was to raise awareness among pediatric dentists about the maxillofacial ramifications of secondary hyperparathyroidism.
机译：一名14岁男性患有家族性低磷酸盐血症性rick病，正在接受口服磷酸盐和骨化三醇疗法的治疗，现呈递给宾夕法尼亚州匹兹堡匹兹堡大学医学中心匹兹堡儿童医院儿科牙科科。全景射线照相显示多焦点下颌骨的多眼病变导致外科探查和活检。最大病变的组织病理学评估显示与中央巨细胞肉芽肿一致的特征。根据患者的病史，怀疑甲状旁腺功能亢进。实验室数据显示甲状旁腺激素升高至152 pg / ml（正常范围等于9到69）。这证实了与继发性甲状旁腺功能亢进有关的下颌中多个棕色肿瘤的诊断，这归因于高剂量磷酸盐治疗。内分泌咨询后，骨化三醇治疗增加。药物治疗有望改善患者的褐色瘤。本病例报告的目的是提高儿科牙医对继发性甲状旁腺功能亢进症颌面部后果的认识。

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